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Materials 2016, 9(4), 304; doi:10.3390/ma9040304

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hannover D-30559, Germany
Division of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, University of Rostock, Rostock D-18057, Germany
Institute for Biomedical Engineering, Rostock University Medical Center, Rostock D-18119, Germany
Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, Hannover D-30559, Germany
Institut fuer Werkstoffkunde, Leibniz Universitaet Hannover, Garbsen D-30823, Germany
Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, Hannover D-30625, Germany
Author to whom correspondence should be addressed.
Academic Editor: Alina Maria Holban
Received: 3 March 2016 / Revised: 14 April 2016 / Accepted: 18 April 2016 / Published: 22 April 2016
(This article belongs to the Special Issue Materials for Hard and Soft Tissue Engineering: Novel Approaches)
View Full-Text   |   Download PDF [5045 KB, uploaded 22 April 2016]   |  


Implant constructs supporting angiogenesis are favorable for treating critically-sized bone defects, as ingrowth of capillaries towards the center of large defects is often insufficient. Consequently, the insufficient nutritional supply of these regions leads to impaired bone healing. Implants with specially designed angiogenic supporting geometry and functionalized with proangiogenic cytokines can enhance angiogenesis. In this study, Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were used for incorporation into poly-ε-caprolactone (PCL)-coated porous titanium implants. Bioactivity of released factors and influence on angiogenesis of functionalized implants were evaluated using a migration assay and angiogenesis assays. Both implants released angiogenic factors, inducing migration of endothelial cells. Also, VEGF-functionalized PCL-coated titanium implants enhanced angiogenesis in vitro. Both factors were rapidly released in high doses from the implant coating during the first 72 h. View Full-Text
Keywords: titanium; angiogenesis; VEGF; HMGB1; functionalized implants; PCL titanium; angiogenesis; VEGF; HMGB1; functionalized implants; PCL

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roland, L.; Backhaus, S.; Grau, M.; Matena, J.; Teske, M.; Beyerbach, M.; Murua Escobar, H.; Haferkamp, H.; Gellrich, N.-C.; Nolte, I. Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro. Materials 2016, 9, 304.

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