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Materials 2016, 9(4), 297; doi:10.3390/ma9040297

Polyelectrolyte-Functionalized Nanofiber Mats Control the Collection and Inactivation of Escherichia coli

Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003-9303, USA
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Academic Editor: Nicole Zander
Received: 30 December 2015 / Revised: 28 March 2016 / Accepted: 12 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Electrospun Materials)
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Abstract

Quantifying the effect that nanofiber mat chemistry and hydrophilicity have on microorganism collection and inactivation is critical in biomedical applications. In this study, the collection and inactivation of Escherichia coli K12 was examined using cellulose nanofiber mats that were surface-functionalized using three polyelectrolytes: poly (acrylic acid) (PAA), chitosan (CS), and polydiallyldimethylammonium chloride (pDADMAC). The polyelectrolyte functionalized nanofiber mats retained the cylindrical morphology and average fiber diameter (~0.84 µm) of the underlying cellulose nanofibers. X-ray photoelectron spectroscopy (XPS) and contact angle measurements confirmed the presence of polycations or polyanions on the surface of the nanofiber mats. Both the control cellulose and pDADMAC-functionalized nanofiber mats exhibited a high collection of E. coli K12, which suggests that mat hydrophilicity may play a larger role than surface charge on cell collection. While the minimum concentration of polycations needed to inhibit E. coli K12 was 800 µg/mL for both CS and pDADMAC, once immobilized, pDADMAC-functionalized nanofiber mats exhibited a higher inactivation of E. coli K12, (~97%). Here, we demonstrate that the collection and inactivation of microorganisms by electrospun cellulose nanofiber mats can be tailored through a facile polyelectrolyte functionalization process. View Full-Text
Keywords: antibacterial; bacteria; cellulose; chitosan; electrospun; inactivation; nanofiber; poly (acrylic acid); polyelectrolyte antibacterial; bacteria; cellulose; chitosan; electrospun; inactivation; nanofiber; poly (acrylic acid); polyelectrolyte
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rieger, K.A.; Porter, M.; Schiffman, J.D. Polyelectrolyte-Functionalized Nanofiber Mats Control the Collection and Inactivation of Escherichia coli. Materials 2016, 9, 297.

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