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Materials 2016, 9(4), 272; doi:10.3390/ma9040272

Electrospun 3D Fibrous Scaffolds for Chronic Wound Repair

1
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
2
Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
3
School of Mechanical Engineering, Ngee Ann Polytechnic, 535 Clementi Road, Singapore 599489, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Nicole Zander
Received: 18 January 2016 / Revised: 16 March 2016 / Accepted: 30 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Electrospun Materials)
View Full-Text   |   Download PDF [2417 KB, uploaded 6 April 2016]   |  

Abstract

Chronic wounds are difficult to heal spontaneously largely due to the corrupted extracellular matrix (ECM) where cell ingrowth is obstructed. Thus, the objective of this study was to develop a three-dimensional (3D) biodegradable scaffold mimicking native ECM to replace the missing or dysfunctional ECM, which may be an essential strategy for wound healing. The 3D fibrous scaffolds of poly(lactic acid-co-glycolic acid) (PLGA) were successfully fabricated by liquid-collecting electrospinning, with 5~20 µm interconnected pores. Surface modification with the native ECM component aims at providing biological recognition for cell growth. Human dermal fibroblasts (HDFs) successfully infiltrated into scaffolds at a depth of ~1400 µm after seven days of culturing, and showed significant progressive proliferation on scaffolds immobilized with collagen type I. In vivo models showed that chronic wounds treated with scaffolds had a faster healing rate. These results indicate that the 3D fibrous scaffolds may be a potential wound dressing for chronic wound repair. View Full-Text
Keywords: electrospinning; tissue engineering; wound healing; PLGA; fibrous scaffolds; surface modification electrospinning; tissue engineering; wound healing; PLGA; fibrous scaffolds; surface modification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, H.; Peng, Y.; Wu, S.; Tan, L.P. Electrospun 3D Fibrous Scaffolds for Chronic Wound Repair. Materials 2016, 9, 272.

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