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Materials 2016, 9(2), 97; doi:10.3390/ma9020097

Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model

1
BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea
2
Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Korea
3
Department of Dental Hygiene, College of Health Science, Gachon University, Incheon 21936, Korea
4
Meta-Biomed Co., Ltd. Institute, 270 Osongsaengmyeong1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk 28161, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Georgios E. Romanos
Received: 9 December 2015 / Accepted: 3 February 2016 / Published: 6 February 2016
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [2366 KB, uploaded 6 February 2016]   |  

Abstract

The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material. View Full-Text
Keywords: silicon-substituted coral hydroxyapatite; beta-tricalcium phosphate; bone graft material; bone regeneration; rat calvarial bone defect model silicon-substituted coral hydroxyapatite; beta-tricalcium phosphate; bone graft material; bone regeneration; rat calvarial bone defect model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Roh, J.; Kim, J.-Y.; Choi, Y.-M.; Ha, S.-M.; Kim, K.-N.; Kim, K.-M. Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model. Materials 2016, 9, 97.

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