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Materials 2016, 9(10), 853; doi:10.3390/ma9100853

Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model

1
First Department of Oral and Maxillofacial Surgery, Osaka Dental University, Hirakata 5731121, Japan
2
Department of Biomaterials, Osaka Dental University; Hirakata 5731121, Japan
3
Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita 5658565, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 14 July 2016 / Revised: 5 October 2016 / Accepted: 13 October 2016 / Published: 19 October 2016
(This article belongs to the Section Biomaterials)
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Abstract

The effect of porous alpha-tricalcium phosphate (α-TCP) with immobilized basic fibroblast growth factor (bFGF) on bone regeneration was evaluated in a canine mandibular bone defect model. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), whereas the other was filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed two, four and eight weeks after implantation. The bone mineral density of the bFGF group was higher than that of the control group at each time point (p < 0.05), and the bone mineral content of the bFGF group was higher than that of the control group at four and eight weeks (p < 0.05). Histological evaluation two weeks after implantation revealed that the porous α-TCP had degraded and bone had formed on the surface of α-TCP particles in the bFGF group. At eight weeks, continuous cortical bone with a Haversian structure covered the top of bone defects in the bFGF group. These findings demonstrate that porous α-TCP with immobilized bFGF can promote bone regeneration. View Full-Text
Keywords: alpha-tricalcium phosphate; basic fibroblast growth factor; bone regeneration alpha-tricalcium phosphate; basic fibroblast growth factor; bone regeneration
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Kobayashi, N.; Hashimoto, Y.; Otaka, A.; Yamaoka, T.; Morita, S. Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model. Materials 2016, 9, 853.

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