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Materials 2015, 8(7), 4176-4190; doi:10.3390/ma8074176

Microscopic Characterization of Individual Submicron Bubbles during the Layer-by-Layer Deposition: Towards Creating Smart Agents

1
Faculty of Pharmaceutical Science, Nagasaki International University, Huis Ten Bosch, Nagasaki 859-3298, Japan
2
Research Center for Materials Science and Engineering, Kochi University of Technology, Tosa-Yamada, Kochi 782-8502, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Navneet Soin
Received: 11 December 2014 / Revised: 13 June 2015 / Accepted: 29 June 2015 / Published: 8 July 2015
(This article belongs to the Special Issue Smart Materials)
View Full-Text   |   Download PDF [778 KB, uploaded 8 July 2015]   |  

Abstract

We investigated the individual properties of various polyion-coated bubbles with a mean diameter ranging from 300 to 500 nm. Dark field microscopy allows one to track the individual particles of the submicron bubbles (SBs) encapsulated by the layer-by-layer (LbL) deposition of cationic and anionic polyelectrolytes (PEs). Our focus is on the two-step charge reversals of PE-SB complexes: the first is a reversal from negatively charged bare SBs with no PEs added to positive SBs encapsulated by polycations (monolayer deposition), and the second is overcharging into negatively charged PE-SB complexes due to the subsequent addition of polyanions (double-layer deposition). The details of these phenomena have been clarified through the analysis of a number of trajectories of various PE-SB complexes that experience either Brownian motion or electrophoresis. The contrasted results obtained from the analysis were as follows: an amount in excess of the stoichiometric ratio of the cationic polymers was required for the first charge-reversal, whereas the stoichiometric addition of the polyanions lead to the electrical neutralization of the PE-SB complex particles. The recovery of the stoichiometry in the double-layer deposition paves the way for fabricating multi-layered SBs encapsulated solely with anionic and cationic PEs, which provides a simple protocol to create smart agents for either drug delivery or ultrasound contrast imaging. View Full-Text
Keywords: microbubble; layer-by-layer; polyelectrolyte; electrophoresis; charge-reversal microbubble; layer-by-layer; polyelectrolyte; electrophoresis; charge-reversal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kato, R.; Frusawa, H. Microscopic Characterization of Individual Submicron Bubbles during the Layer-by-Layer Deposition: Towards Creating Smart Agents. Materials 2015, 8, 4176-4190.

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