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Materials 2015, 8(12), 8097-8105; doi:10.3390/ma8125440

Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template

1
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 26 October 2015 / Revised: 16 November 2015 / Accepted: 20 November 2015 / Published: 30 November 2015
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [4735 KB, uploaded 30 November 2015]   |  

Abstract

In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications. View Full-Text
Keywords: chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, J.; Liu, G.; Chen, J.; Zhao, B.; Zhu, P. Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template. Materials 2015, 8, 8097-8105.

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