Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials
AbstractCalcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption in vivo. This allows for the space to be created for the new bone tissue to form and infiltrate within the implanted graft material. Several factors affect the biodegradation and resorption of calcium phosphate materials after implantation. Various cell types are involved in the degradation process by phagocytic mechanisms (monocytes/macrophages, fibroblasts, osteoblasts) or via an acidic mechanism to reduce the micro-environmental pH which results in demineralization of the cement matrix and resorption via osteoclasts. These cells exert their degradation effects directly or indirectly through the cytokine growth factor secretion and their sensitivity and response to these biomolecules. This article discusses the mechanisms of calcium phosphate material degradation in vivo. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Sheikh, Z.; Abdallah, M.-N.; Hanafi, A.A.; Misbahuddin, S.; Rashid, H.; Glogauer, M. Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials. Materials 2015, 8, 7913-7925.
Sheikh Z, Abdallah M-N, Hanafi AA, Misbahuddin S, Rashid H, Glogauer M. Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials. Materials. 2015; 8(11):7913-7925.Chicago/Turabian Style
Sheikh, Zeeshan; Abdallah, Mohamed-Nur; Hanafi, Ahmed A.; Misbahuddin, Syed; Rashid, Haroon; Glogauer, Michael. 2015. "Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials." Materials 8, no. 11: 7913-7925.