Next Article in Journal
Sulfadiazineā€”Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds
Next Article in Special Issue
Hybrid Membranes of PLLA/Collagen for Bone Tissue Engineering: A Comparative Study of Scaffold Production Techniques for Optimal Mechanical Properties and Osteoinduction Ability
Previous Article in Journal
Characterization of the Microstructure Evolution in IF-Steel and AA6016 during Plane-Strain Tension and Simple Shear
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(1), 302-316; doi:10.3390/ma8010302

Evaluation of Biaxial Mechanical Properties of Aortic Media Based on the Lamellar Microstructure

1
Cardiovascular Engineering Laboratory, Faculty of Biomedical Engineering, Amirkabir University of Technology, 424 Hafez Ave., Tehran 15875-4413, Iran
2
Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), ShahidBeheshti University of Medical Sciences, Tehran 19575-154, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Amir A. Zadpoor
Received: 3 December 2014 / Accepted: 7 January 2015 / Published: 16 January 2015
(This article belongs to the Special Issue Mechanics of Biomaterials)
View Full-Text   |   Download PDF [875 KB, uploaded 16 January 2015]   |  

Abstract

Evaluation of the mechanical properties of arterial wall components is necessary for establishing a precise mechanical model applicable in various physiological and pathological conditions, such as remodeling. In this contribution, a new approach for the evaluation of the mechanical properties of aortic media accounting for the lamellar structure is proposed. We assumed aortic media to be composed of two sets of concentric layers, namely sheets of elastin (Layer I) and interstitial layers composed of mostly collagen bundles, fine elastic fibers and smooth muscle cells (Layer II). Biaxial mechanical tests were carried out on human thoracic aortic samples, and histological staining was performed to distinguish wall lamellae for determining the dimensions of the layers. A neo-Hookean strain energy function (SEF) for Layer I and a four-parameter exponential SEF for Layer II were allocated. Nonlinear regression was used to find the material parameters of the proposed microstructural model based on experimental data. The non-linear behavior of media layers confirmed the higher contribution of elastic tissue in lower strains and the gradual engagement of collagen fibers. The resulting model determines the nonlinear anisotropic behavior of aortic media through the lamellar microstructure and can be assistive in the study of wall remodeling due to alterations in lamellar structure during pathological conditions and aging. View Full-Text
Keywords: aortic media; lamellar structure; microstructural modeling; strain energy function aortic media; lamellar structure; microstructural modeling; strain energy function
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Taghizadeh, H.; Tafazzoli-Shadpour, M.; Shadmehr, M.B.; Fatouraee, N. Evaluation of Biaxial Mechanical Properties of Aortic Media Based on the Lamellar Microstructure. Materials 2015, 8, 302-316.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top