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Materials 2015, 8(1), 317-338; doi:10.3390/ma8010317

Sulfadiazine—Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds

1
Petru Poni" Institute of Macromolecular Chemistry, Department of Physical Chemistry of Polymers, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
2
Grigore T. Popa" University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 16 University Street, 700115 Iasi, Romania
3
Grigore T. Popa" University of Medicine and Pharmacy, Faculty of Medicine, Department of Plastic and Reconstructive Surgery, 16 University Street, 700115 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Heather Sheardown
Received: 24 October 2014 / Accepted: 23 December 2014 / Published: 16 January 2015
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [1628 KB, uploaded 16 January 2015]   |  

Abstract

In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform—Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: Escherichia coli, Listeria monocytogenes and Salmonella thyphymurium. The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan. View Full-Text
Keywords: chitosan; hyaluronic acid; sulfadiazine; polyelectrolyte complex; burn wound chitosan; hyaluronic acid; sulfadiazine; polyelectrolyte complex; burn wound
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dumitriu, R.P.; Profire, L.; Nita, L.E.; Dragostin, O.M.; Ghetu, N.; Pieptu, D.; Vasile, C. Sulfadiazine—Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds. Materials 2015, 8, 317-338.

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