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Materials 2014, 7(8), 5470-5487; doi:10.3390/ma7085470

Bioactivity of Sodium Free Fluoride Containing Glasses and Glass-Ceramics

1
Dental Physical Science, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK
2
Otto-Schott-Institut, Friedrich-Schiller-Universität, Fraunhoferstr. 6, Jena 07743, Germany
3
School of Engineering and Materials Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
*
Author to whom correspondence should be addressed.
Received: 14 May 2014 / Revised: 16 July 2014 / Accepted: 18 July 2014 / Published: 25 July 2014
(This article belongs to the Section Biomaterials)
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Abstract

The bioactivity of a series of fluoride-containing sodium-free calcium and strontium phosphosilicate glasses has been tested in vitro. Glasses with high fluoride content were partially crystallised to apatite and other fluoride-containing phases. The bioactivity study was carried out in Tris and SBF buffers, and apatite formation was monitored by XRD, FTIR and solid state NMR. Ion release in solutions has been measured using ICP-OES and fluoride-ion selective electrode. The results show that glasses with low amounts of fluoride that were initially amorphous degraded rapidly in Tris buffer and formed apatite as early as 3 h after immersion. The apatite was identified as fluorapatite by 19F MAS-NMR after 6 h of immersion. Glass degradation and apatite formation was significantly slower in SBF solution compared to Tris. On immersion of the partially crystallised glasses, the fraction of apatite increased at 3 h compared to the amount of apatite prior to the treatment. Thus, partial crystallisation of the glasses has not affected bioactivity significantly. Fast dissolution of the amorphous phase was also indicated. There was no difference in kinetics between Tris and SBF studies when the glass was partially crystallised to apatite before immersion. Two different mechanisms of apatite formation for amorphous or partially crystallised glasses are discussed. View Full-Text
Keywords: sodium-/alkali-free bioactive glass; bioactive glass-ceramics; fluorapatite; fluoride sodium-/alkali-free bioactive glass; bioactive glass-ceramics; fluorapatite; fluoride
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MDPI and ACS Style

Chen, X.; Chen, X.; Brauer, D.S.; Wilson, R.M.; Hill, R.G.; Karpukhina, N. Bioactivity of Sodium Free Fluoride Containing Glasses and Glass-Ceramics. Materials 2014, 7, 5470-5487.

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