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Materials 2014, 7(6), 4105-4117; doi:10.3390/ma7064105

Biocompatibility and Surface Properties of TiO2 Thin Films Deposited by DC Magnetron Sputtering

1
Centro de Investigación en Micro y Nanotecnología, Universidad Veracruzana, Calzada Ruiz Cortines 455, 94294 Boca del Río, Veracruz, Mexico
2
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Av. San Claudio 6301, Col. San Manuel, 72570 Puebla, Mexico
3
Licenciatura en Biomedicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2702, Col. Volcanes, 72410 Puebla, Mexico
*
Author to whom correspondence should be addressed.
Received: 10 April 2014 / Revised: 1 May 2014 / Accepted: 5 May 2014 / Published: 27 May 2014
(This article belongs to the Section Biomaterials)
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Abstract

We present the study of the biocompatibility and surface properties of titanium dioxide (TiO2) thin films deposited by direct current magnetron sputtering. These films are deposited on a quartz substrate at room temperature and annealed with different temperatures (100, 300, 500, 800 and 1100 °C). The biocompatibility of the TiO2 thin films is analyzed using primary cultures of dorsal root ganglion (DRG) of Wistar rats, whose neurons are incubated on the TiO2 thin films and on a control substrate during 18 to 24 h. These neurons are activated by electrical stimuli and its ionic currents and action potential activity recorded. Through X-ray diffraction (XRD), the surface of TiO2 thin films showed a good quality, homogeneity and roughness. The XRD results showed the anatase to rutile phase transition in TiO2 thin films at temperatures between 500 and 1100 °C. This phase had a grain size from 15 to 38 nm, which allowed a suitable structural and crystal phase stability of the TiO2 thin films for low and high temperature. The biocompatibility experiments of these films indicated that they were appropriated for culture of living neurons which displayed normal electrical behavior. View Full-Text
Keywords: biocompatibility; dorsal root ganglion neurons; direct current magnetron sputtering; thin film; TiO2 biocompatibility; dorsal root ganglion neurons; direct current magnetron sputtering; thin film; TiO2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

López-Huerta, F.; Cervantes, B.; González, O.; Hernández-Torres, J.; García-González, L.; Vega, R.; Herrera-May, A.L.; Soto, E. Biocompatibility and Surface Properties of TiO2 Thin Films Deposited by DC Magnetron Sputtering. Materials 2014, 7, 4105-4117.

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