Next Article in Journal
CO2 Capture and Separation Properties in the Ionic Liquid 1-n-Butyl-3-Methylimidazolium Nonafluorobutylsulfonate
Previous Article in Journal
Porous Gold Films—A Short Review on Recent Progress
Materials 2014, 7(5), 3855-3866; doi:10.3390/ma7053855
Article

Effect of Receptor Structure and Length on the Wrapping of a Nanoparticle by a Lipid Membrane

1,2
, 1,3
, 1
, 1,*  and 1,4,*
Received: 4 April 2014; in revised form: 30 April 2014 / Accepted: 4 May 2014 / Published: 14 May 2014
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [1360 KB, uploaded 14 May 2014]   |   Browse Figures
Abstract: Nanoparticles have been considered as a type of powerful tool to deliver drugs and genes into cells for disease diagnosis and therapies. It has been generally accepted that the internalization of nanoparticles into cells is mostly realized by receptor-mediated endocytosis. However, for the influence of structural factors of receptors on endocytosis, this is still largely unknown. In this paper, computer simulations are applied to investigate the effects of structure (i.e., the number of constituent chains of the receptor) and the length of the receptor on the wrapping behavior of nanoparticles by the lipid membrane, which is a key step of receptor-medicated endocytosis. It is found that these structural factors of receptors have strong effects on the nanoparticle’s final interaction configuration with the membrane in the simulations, such as adhering on the membrane surface or being partly or fully wrapped by the membrane. Furthermore, in some cases, the rupture of the lipid membrane occurs. These results are helpful for the understanding of endocytosis and the preparation of advanced nanoscale drug-delivery vectors.
Keywords: lipid membrane; nanoparticle; receptor; endocytosis; computer simulations lipid membrane; nanoparticle; receptor; endocytosis; computer simulations
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Zhang, H.; Wang, L.; Yuan, B.; Yang, K.; Ma, Y. Effect of Receptor Structure and Length on the Wrapping of a Nanoparticle by a Lipid Membrane. Materials 2014, 7, 3855-3866.

AMA Style

Zhang H, Wang L, Yuan B, Yang K, Ma Y. Effect of Receptor Structure and Length on the Wrapping of a Nanoparticle by a Lipid Membrane. Materials. 2014; 7(5):3855-3866.

Chicago/Turabian Style

Zhang, Haizhen; Wang, Ling; Yuan, Bing; Yang, Kai; Ma, Yuqiang. 2014. "Effect of Receptor Structure and Length on the Wrapping of a Nanoparticle by a Lipid Membrane." Materials 7, no. 5: 3855-3866.


Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert