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Materials 2014, 7(4), 3106-3135; doi:10.3390/ma7043106

Gelatin-Based Materials in Ocular Tissue Engineering

1 School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK 2 Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy 3 Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK 4 Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham NG7 2RD, UK Authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 February 2014 / Revised: 17 March 2014 / Accepted: 24 March 2014 / Published: 17 April 2014
(This article belongs to the Special Issue Biocompatibility of Materials 2013)
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Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively evaluated for numerous ocular applications serving as cell-sheet carriers, bio-adhesives and bio-artificial grafts. These different applications naturally have diverse physical, chemical and biological requirements and this has prompted research into the modification of gelatin and its derivatives. The crosslinking of gelatin alone or in combination with natural or synthetic biopolymers has produced a variety of scaffolds that could be suitable for ocular applications. This review focuses on methods to crosslink gelatin-based materials and how the resulting materials have been applied in ocular tissue engineering. Critical discussion of recent innovations in tissue engineering and regenerative medicine will highlight future opportunities for gelatin-based materials in ophthalmology.
Keywords: gelatin; tissue engineering; ophthalmology; biocompatibility; cornea; retinal epithelium gelatin; tissue engineering; ophthalmology; biocompatibility; cornea; retinal epithelium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rose, J.B.; Pacelli, S.; Haj, A.J.E.; Dua, H.S.; Hopkinson, A.; White, L.J.; Rose, F.R.A.J. Gelatin-Based Materials in Ocular Tissue Engineering. Materials 2014, 7, 3106-3135.

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