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Materials 2014, 7(4), 3106-3135; doi:10.3390/ma7043106
Review

Gelatin-Based Materials in Ocular Tissue Engineering

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, 1,†
 and 1,†,*
Received: 4 February 2014; in revised form: 17 March 2014 / Accepted: 24 March 2014 / Published: 17 April 2014
(This article belongs to the Special Issue Biocompatibility of Materials 2013)
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Abstract: Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively evaluated for numerous ocular applications serving as cell-sheet carriers, bio-adhesives and bio-artificial grafts. These different applications naturally have diverse physical, chemical and biological requirements and this has prompted research into the modification of gelatin and its derivatives. The crosslinking of gelatin alone or in combination with natural or synthetic biopolymers has produced a variety of scaffolds that could be suitable for ocular applications. This review focuses on methods to crosslink gelatin-based materials and how the resulting materials have been applied in ocular tissue engineering. Critical discussion of recent innovations in tissue engineering and regenerative medicine will highlight future opportunities for gelatin-based materials in ophthalmology.
Keywords: gelatin; tissue engineering; ophthalmology; biocompatibility; cornea; retinal epithelium gelatin; tissue engineering; ophthalmology; biocompatibility; cornea; retinal epithelium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rose, J.B.; Pacelli, S.; Haj, A.J.E.; Dua, H.S.; Hopkinson, A.; White, L.J.; Rose, F.R.A.J. Gelatin-Based Materials in Ocular Tissue Engineering. Materials 2014, 7, 3106-3135.

AMA Style

Rose JB, Pacelli S, Haj AJE, Dua HS, Hopkinson A, White LJ, Rose FRAJ. Gelatin-Based Materials in Ocular Tissue Engineering. Materials. 2014; 7(4):3106-3135.

Chicago/Turabian Style

Rose, James B.; Pacelli, Settimio; Haj, Alicia J.E.; Dua, Harminder S.; Hopkinson, Andrew; White, Lisa J.; Rose, Felicity R.A.J. 2014. "Gelatin-Based Materials in Ocular Tissue Engineering." Materials 7, no. 4: 3106-3135.


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