Next Article in Journal
Homogenized Elastic Properties of Graphene for Small Deformations
Previous Article in Journal
Nanoscale Design of Nano-Sized Particles in Shape-Memory Polymer Nanocomposites Driven by Electricity
Materials 2013, 6(9), 3755-3763; doi:10.3390/ma6093755
Article

Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome

1
,
1,2,* , 1,2
,
1
,
1
,
1,2
 and
1,2
1 College of Chemical Engineering, Huaqiao University, Xiamen 361021, China 2 Institutes of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China
* Author to whom correspondence should be addressed.
Received: 7 June 2013 / Revised: 29 July 2013 / Accepted: 30 August 2013 / Published: 3 September 2013
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [389 KB, uploaded 3 September 2013]   |   Browse Figures
SciFeed

Abstract

To ease the side effects triggered by cytosine arabinoside (Ara-C) for acute leukemia treatment, a novel magnetic targeting anti-tumor drug delivery system was constructed through bacterial magnetosomes (BMs) from Magnetospirillum magneticum AMB-1 combined with Ara-C by crosslinking of genipin (GP). The results showed that Ara-C could be bonded onto the membrane surface of BMs effectively through chemical crosslinking induced by dual hand reagents GP. The average diameters of BMs and Ara-C-coupled BMs (ABMs) were 42.0 ± 8.6 and 72.7 ± 6.0 nm respectively, and the zeta potentials (−38.1 ± 9.1) revealed that these systems were stable, confirming the stability of the system. The optimal encapsulation efficiency and drug loading were 89.05% ± 2.33% and 47.05% ± 0.64% respectively when crosslinking reaction lasted for 72 h. The system also presented long-term stability and release behaviors without initial burst release (Ara-C could be released 80% within three months). Our results indicate that BMs have great potential in biomedical and clinical fields as a novel anti-tumor drug carrier.
Keywords: cytosine arabinoside; magnetosome; genipin; drug release cytosine arabinoside; magnetosome; genipin; drug release
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Deng, Q.; Liu, Y.; Wang, S.; Xie, M.; Wu, S.; Chen, A.; Wu, W. Construction of a Novel Magnetic Targeting Anti-Tumor Drug Delivery System: Cytosine Arabinoside-Loaded Bacterial Magnetosome. Materials 2013, 6, 3755-3763.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert