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Materials 2013, 6(5), 1599-1607; doi:10.3390/ma6051599
Article

From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

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Received: 18 February 2013 / Revised: 7 April 2013 / Accepted: 22 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Advances in Mesoporous Materials)
Download PDF [1396 KB, 8 May 2013; original version 29 April 2013]

Abstract

The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52, p < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 vs. 2.17 ± 0.75, p < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11 vs. 5 ± 5.48, p < 0.05).
Keywords: bio-collagen; leather waste valorisation; wound healing; tissue regeneration bio-collagen; leather waste valorisation; wound healing; tissue regeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Catalina, M.; Cot, J.; Borras, M.; Lapuente, J.D.; González, J.; Balu, A.M.; Luque, R. From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing. Materials 2013, 6, 1599-1607.

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