Abstract: Chitosonic® Acid, carboxymethyl hexanoyl chitosan, is a novel chitosan material that has recently been accepted by the Personal Care Products Council as a new cosmetic ingredient with the INCI (International Nomenclature of Cosmetic Ingredients) name Carboxymethyl Caprooyl Chitosan. In this study, we analyze several important cosmetic characteristics of Chitosonic® Acid. Our results demonstrate that Chitosonic® Acid is a water-soluble chitosan derivative with a high HLB value. Chitosonic® Acid can form a nano-network structure when its concentration is higher than 0.5% and can self-assemble into a nanosphere structure when its concentration is lower than 0.2%. Chitosonic® Acid has potent antimicrobial activities against gram-positive bacteria, gram-negative bacteria and fungus. Chitosonic® Acid also has moderate DPPH radical scavenging activity. Additionally, Chitosonic® Acid exhibits good hydration activity for absorbing and retaining water molecules with its hydrophilic groups. From a safety point of view, Chitosonic® Acid has no cytotoxicity to L-929 cells if its concentration is less than 0.5%. Moreover, Chitosonic® Acid has good compatibilities with various normal cosmetic ingredients. Therefore, we propose that Chitosonic® Acid has the potential to be a widely used ingredient in various types of cosmetic products.
Keywords: antimicrobial activity; antioxidant activity; Carboxymethyl Caprooyl Chitosan; Chitosonic® Acid; cosmetic ingredient; hydration activity
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Lee, S.-M.; Liu, K.-H.; Liu, Y.-Y.; Chang, Y.-P.; Lin, C.-C.; Chen, Y.-S. Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities. Materials 2013, 6, 1391-1402.
Lee S-M, Liu K-H, Liu Y-Y, Chang Y-P, Lin C-C, Chen Y-S. Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities. Materials. 2013; 6(4):1391-1402.
Lee, Shu-Mei; Liu, Kun-Ho; Liu, Yen-Yu; Chang, Yen-Po; Lin, Chih-Chien; Chen, Yi-Shyan. 2013. "Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities." Materials 6, no. 4: 1391-1402.