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Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities
Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan
Advanced Delivery Technology Co. Ltd, 5F, D Building, No.120, Zhonghua Rd., Hsinchu Industrial Park, Hukou Township, Hsinchu 30352, Taiwan
Department of Cosmetic Science, Providence University, No. 200, Sec. 7, Taiwan Boulevard, Shalu, Taichung 43301, Taiwan
* Authors to whom correspondence should be addressed.
Received: 30 November 2012; in revised form: 22 February 2013 / Accepted: 20 March 2013 / Published: 28 March 2013
Abstract: Chitosonic® Acid, carboxymethyl hexanoyl chitosan, is a novel chitosan material that has recently been accepted by the Personal Care Products Council as a new cosmetic ingredient with the INCI (International Nomenclature of Cosmetic Ingredients) name Carboxymethyl Caprooyl Chitosan. In this study, we analyze several important cosmetic characteristics of Chitosonic® Acid. Our results demonstrate that Chitosonic® Acid is a water-soluble chitosan derivative with a high HLB value. Chitosonic® Acid can form a nano-network structure when its concentration is higher than 0.5% and can self-assemble into a nanosphere structure when its concentration is lower than 0.2%. Chitosonic® Acid has potent antimicrobial activities against gram-positive bacteria, gram-negative bacteria and fungus. Chitosonic® Acid also has moderate DPPH radical scavenging activity. Additionally, Chitosonic® Acid exhibits good hydration activity for absorbing and retaining water molecules with its hydrophilic groups. From a safety point of view, Chitosonic® Acid has no cytotoxicity to L-929 cells if its concentration is less than 0.5%. Moreover, Chitosonic® Acid has good compatibilities with various normal cosmetic ingredients. Therefore, we propose that Chitosonic® Acid has the potential to be a widely used ingredient in various types of cosmetic products.
Keywords: antimicrobial activity; antioxidant activity; Carboxymethyl Caprooyl Chitosan; Chitosonic® Acid; cosmetic ingredient; hydration activity
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MDPI and ACS Style
Lee, S.-M.; Liu, K.-H.; Liu, Y.-Y.; Chang, Y.-P.; Lin, C.-C.; Chen, Y.-S. Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities. Materials 2013, 6, 1391-1402.
Lee S-M, Liu K-H, Liu Y-Y, Chang Y-P, Lin C-C, Chen Y-S. Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities. Materials. 2013; 6(4):1391-1402.
Lee, Shu-Mei; Liu, Kun-Ho; Liu, Yen-Yu; Chang, Yen-Po; Lin, Chih-Chien; Chen, Yi-Shyan. 2013. "Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities." Materials 6, no. 4: 1391-1402.