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Materials 2013, 6(4), 1391-1402; https://doi.org/10.3390/ma6041391

Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities

1
Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan
2
Advanced Delivery Technology Co. Ltd, 5F, D Building, No.120, Zhonghua Rd., Hsinchu Industrial Park, Hukou Township, Hsinchu 30352, Taiwan
3
Department of Cosmetic Science, Providence University, No. 200, Sec. 7, Taiwan Boulevard, Shalu, Taichung 43301, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 30 November 2012 / Revised: 22 February 2013 / Accepted: 20 March 2013 / Published: 28 March 2013
(This article belongs to the Special Issue Advances in Cosmetics)
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Abstract

Chitosonic® Acid, carboxymethyl hexanoyl chitosan, is a novel chitosan material that has recently been accepted by the Personal Care Products Council as a new cosmetic ingredient with the INCI (International Nomenclature of Cosmetic Ingredients) name Carboxymethyl Caprooyl Chitosan. In this study, we analyze several important cosmetic characteristics of Chitosonic® Acid. Our results demonstrate that Chitosonic® Acid is a water-soluble chitosan derivative with a high HLB value. Chitosonic® Acid can form a nano-network structure when its concentration is higher than 0.5% and can self-assemble into a nanosphere structure when its concentration is lower than 0.2%. Chitosonic® Acid has potent antimicrobial activities against gram-positive bacteria, gram-negative bacteria and fungus. Chitosonic® Acid also has moderate DPPH radical scavenging activity. Additionally, Chitosonic® Acid exhibits good hydration activity for absorbing and retaining water molecules with its hydrophilic groups. From a safety point of view, Chitosonic® Acid has no cytotoxicity to L-929 cells if its concentration is less than 0.5%. Moreover, Chitosonic® Acid has good compatibilities with various normal cosmetic ingredients. Therefore, we propose that Chitosonic® Acid has the potential to be a widely used ingredient in various types of cosmetic products. View Full-Text
Keywords: antimicrobial activity; antioxidant activity; Carboxymethyl Caprooyl Chitosan; Chitosonic® Acid; cosmetic ingredient; hydration activity antimicrobial activity; antioxidant activity; Carboxymethyl Caprooyl Chitosan; Chitosonic® Acid; cosmetic ingredient; hydration activity
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Lee, S.-M.; Liu, K.-H.; Liu, Y.-Y.; Chang, Y.-P.; Lin, C.-C.; Chen, Y.-S. Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities. Materials 2013, 6, 1391-1402.

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