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Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Tűzoltó 37-47, Budapest H-1094, Hungary
Department of Orthopedics, Semmelweis University, Karolina 27, Budapest H-1113, Hungary
Department of Interfaces and Surface Modification, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences, Pusztaszeri 59-67, Budapest H-1025, Hungary
Department of Physical Chemistry and Material Science, Budapest University of Technology and Economics, Műegyetem 3, Budapest H-1111, Hungary
* Author to whom correspondence should be addressed.
Received: 1 November 2012; in revised form: 22 January 2013 / Accepted: 24 January 2013 / Published: 15 February 2013
Abstract: Biodegradable scaffolds are widely used to transplant stem cells into various tissues. Recent studies showed that living stem cells can be attached to the surface of absorbable sutures in vitro. Soaking the absorbable material polyglactin in a cell culture medium and thereby creating a stem cell biofilm on its surface may initiate the absorption process even before implantation; therefore, the physicochemical properties of the suture may be compromised in vivo. We found that pre-incubation of sutures in cell culture media in vitro results in tensile strength reduction and faster suture absorption in a rat model of muscle injury. Shorter incubation times of up to 48 h do not influence absorption or tensility; therefore, it is advisable to limit incubation times to two days for polyglactin-based cell delivery protocols.
Keywords: absorbable suture; stem cell; cell therapy; tensile properties; absorption
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Horváthy, D.B.; Vácz, G.; Szabó, T.; Renner, K.; Vajda, K.; Sándor, B.; Lacza, Z. Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation. Materials 2013, 6, 544-550.
Horváthy DB, Vácz G, Szabó T, Renner K, Vajda K, Sándor B, Lacza Z. Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation. Materials. 2013; 6(2):544-550.
Horváthy, Dénes B.; Vácz, Gabriella; Szabó, Tamás; Renner, Károly; Vajda, Kinga; Sándor, Balázs; Lacza, Zsombor. 2013. "Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation." Materials 6, no. 2: 544-550.