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Materials 2013, 6(2), 544-550; doi:10.3390/ma6020544
Communication

Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation

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Received: 1 November 2012; in revised form: 22 January 2013 / Accepted: 24 January 2013 / Published: 15 February 2013
(This article belongs to the Section Biomaterials)
Download PDF [1046 KB, uploaded 15 February 2013]
Abstract: Biodegradable scaffolds are widely used to transplant stem cells into various tissues. Recent studies showed that living stem cells can be attached to the surface of absorbable sutures in vitro. Soaking the absorbable material polyglactin in a cell culture medium and thereby creating a stem cell biofilm on its surface may initiate the absorption process even before implantation; therefore, the physicochemical properties of the suture may be compromised in vivo. We found that pre-incubation of sutures in cell culture media in vitro results in tensile strength reduction and faster suture absorption in a rat model of muscle injury. Shorter incubation times of up to 48 h do not influence absorption or tensility; therefore, it is advisable to limit incubation times to two days for polyglactin-based cell delivery protocols.
Keywords: absorbable suture; stem cell; cell therapy; tensile properties; absorption absorbable suture; stem cell; cell therapy; tensile properties; absorption
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Horváthy, D.B.; Vácz, G.; Szabó, T.; Renner, K.; Vajda, K.; Sándor, B.; Lacza, Z. Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation. Materials 2013, 6, 544-550.

AMA Style

Horváthy DB, Vácz G, Szabó T, Renner K, Vajda K, Sándor B, Lacza Z. Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation. Materials. 2013; 6(2):544-550.

Chicago/Turabian Style

Horváthy, Dénes B.; Vácz, Gabriella; Szabó, Tamás; Renner, Károly; Vajda, Kinga; Sándor, Balázs; Lacza, Zsombor. 2013. "Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation." Materials 6, no. 2: 544-550.


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