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Materials 2013, 6(12), 5763-5795; doi:10.3390/ma6125763
Review

Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis

1,†
, 2,†
 and 3,4,5,6,*
Received: 24 July 2013; in revised form: 14 October 2013 / Accepted: 18 October 2013 / Published: 9 December 2013
(This article belongs to the Section Biomaterials)
Download PDF [917 KB, uploaded 9 December 2013]
Abstract: Semiconductor quantum dots (QDs) or nanoparticles (NPs) exhibit very unusual physico-chemcial and optical properties. This review article introduces the applications of semiconductor nanomaterials (NMs) in fluorescence spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for biomolecule analysis. Due to their unique physico-chemical and optical properties, semiconductors NMs have created many new platforms for investigating biomolecular structures and information in modern biology. These semiconductor NMs served as effective fluorescent probes for sensing proteins and cells and acted as affinity or concentrating probes for enriching peptides, proteins and bacteria proteins prior to MALDI-MS analysis.
Keywords: quantum dots; fluorescent and affinity probes; biomolecules; fluorescence spectroscopy; MALDI-MS quantum dots; fluorescent and affinity probes; biomolecules; fluorescence spectroscopy; MALDI-MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kailasa, S.K.; Cheng, K.-H.; Wu, H.-F. Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis. Materials 2013, 6, 5763-5795.

AMA Style

Kailasa SK, Cheng K-H, Wu H-F. Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis. Materials. 2013; 6(12):5763-5795.

Chicago/Turabian Style

Kailasa, Suresh K.; Cheng, Kuang-Hung; Wu, Hui-Fen. 2013. "Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis." Materials 6, no. 12: 5763-5795.


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