Materials 2011, 4(3), 543-552; doi:10.3390/ma4030543
Article

Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties

1,* email and 2email
Received: 15 January 2011; in revised form: 20 February 2011 / Accepted: 24 February 2011 / Published: 2 March 2011
(This article belongs to the Special Issue Recent Advances in Stimuli-Responsive Materials)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this paper, a novel gelatin-based hydrogel was synthesized through crosslinking graft copolymerization of methacrylic acid (MAA) onto gelatin, using ammonium persulfate (APS) as a free radical initiator in the presence of methylenebisacrylamide (MBA) as a crosslinker. A proposed mechanism for hydrogel formation was suggested and the structure of the product was established using FTIR spectroscopy and gravimetric analysis of the products. Moreover, morphology of the samples was examined by scanning electron microscopy (SEM) and thermogravimetric analysis (TGA/DTG). The effect of reaction variables such as concentration of APS and MBA were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. The gelatin-g-PMAA hydrogel exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pHs 2 and 8. This on-off switching behavior makes the hydrogel as a good candidate for controlled delivery of bioactive agents.
Keywords: gelatin; methacrylic acid; graft copolymers
PDF Full-text Download PDF Full-Text [379 KB, uploaded 2 March 2011 10:36 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Sadeghi, M.; Heidari, B. Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties. Materials 2011, 4, 543-552.

AMA Style

Sadeghi M, Heidari B. Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties. Materials. 2011; 4(3):543-552.

Chicago/Turabian Style

Sadeghi, Mohammad; Heidari, Behrouz. 2011. "Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties." Materials 4, no. 3: 543-552.

Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert