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Materials 2011, 4(1), 84-102; doi:10.3390/ma4010084
Review

Optical and Electric Multifunctional CMOS Image Sensors for On-Chip Biosensing Applications

1,2,* , 1
,
1
 and
1
1 Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan 2 PRESTO, Japan Science and Technology Agency, 3–5 Sanba, Chiyoda, Tokyo, 102-0075, Japan
* Author to whom correspondence should be addressed.
Received: 10 December 2010 / Accepted: 27 December 2010 / Published: 29 December 2010
(This article belongs to the Special Issue Bio-devices and Materials)
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Abstract

In this review, the concept, design, performance, and a functional demonstration of multifunctional complementary metal-oxide-semiconductor (CMOS) image sensors dedicated to on-chip biosensing applications are described. We developed a sensor architecture that allows flexible configuration of a sensing pixel array consisting of optical and electric sensing pixels, and designed multifunctional CMOS image sensors that can sense light intensity and electric potential or apply a voltage to an on-chip measurement target. We describe the sensors’ architecture on the basis of the type of electric measurement or imaging functionalities.
Keywords: CMOS image sensor; on-chip imaging; electric imaging CMOS image sensor; on-chip imaging; electric imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tokuda, T.; Noda, T.; Sasagawa, K.; Ohta, J. Optical and Electric Multifunctional CMOS Image Sensors for On-Chip Biosensing Applications. Materials 2011, 4, 84-102.

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