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Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering
Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
* Author to whom correspondence should be addressed.
Received: 20 May 2010; Accepted: 29 June 2010 / Published: 6 July 2010
Abstract: Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.
Keywords: bioactive glasses; glass-ceramics; melt-derived glasses; scaffolds; bone; tissue engineering; composites; ion release; osteogenesis; angiogenesis
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MDPI and ACS Style
Gerhardt, L.-C.; Boccaccini, A.R. Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering. Materials 2010, 3, 3867-3910.
Gerhardt L-C, Boccaccini AR. Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering. Materials. 2010; 3(7):3867-3910.
Gerhardt, Lutz-Christian; Boccaccini, Aldo R. 2010. "Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering." Materials 3, no. 7: 3867-3910.