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Materials 2010, 3(6), 3714-3728; doi:10.3390/ma3063714
Article

Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation

1,2,* , 1
, 3
 and 4
Received: 4 May 2010; Accepted: 17 June 2010 / Published: 19 June 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Download PDF [462 KB, uploaded 19 June 2010]
Abstract: Studies using cellular therapies, scaffolds, and tubular structured implants have been carried out with the goal to restore functional recovery after spinal cord injury (SCI). None of these therapeutic strategies, by themselves, have been shown to be sufficient to achieve complete restoration of function. To reverse the devastating effects of SCI, an interdisciplinary approach that combines materials science and engineering, stem cell biology, and neurosurgery is being carried out. We are currently investigating a scaffold that has the ability to deliver growth factors for the proliferation and differentiation of endogenous stem cells. Neural stem cells (NSCs) derived from mice are being used to assess the efficacy of the release of growth factors from the scaffold in vitro. The fabrication of the tubular implant allows a porous scaffold to be formed, which aids in the release of growth factors added to the scaffold.
Keywords: neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hackett, J.M.; Dang, T.T.; Tsai, E.C.; Cao, X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials 2010, 3, 3714-3728.

AMA Style

Hackett JM, Dang TT, Tsai EC, Cao X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials. 2010; 3(6):3714-3728.

Chicago/Turabian Style

Hackett, Joanne M.; Dang, ThucNhi T.; Tsai, Eve C.; Cao, Xudong. 2010. "Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation." Materials 3, no. 6: 3714-3728.


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