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Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
Department of Clinical and Experimental Medicine, Linköping University, 581 85 Linköping, Sweden
Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, K1Y 4E9, Canada
Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis-Pasteur, Ottawa, Ontario, K1N 6N5, Canada
* Author to whom correspondence should be addressed.
Received: 4 May 2010; Accepted: 17 June 2010 / Published: 19 June 2010
Abstract: Studies using cellular therapies, scaffolds, and tubular structured implants have been carried out with the goal to restore functional recovery after spinal cord injury (SCI). None of these therapeutic strategies, by themselves, have been shown to be sufficient to achieve complete restoration of function. To reverse the devastating effects of SCI, an interdisciplinary approach that combines materials science and engineering, stem cell biology, and neurosurgery is being carried out. We are currently investigating a scaffold that has the ability to deliver growth factors for the proliferation and differentiation of endogenous stem cells. Neural stem cells (NSCs) derived from mice are being used to assess the efficacy of the release of growth factors from the scaffold in vitro. The fabrication of the tubular implant allows a porous scaffold to be formed, which aids in the release of growth factors added to the scaffold.
Keywords: neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation
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Hackett, J.M.; Dang, T.T.; Tsai, E.C.; Cao, X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials 2010, 3, 3714-3728.
Hackett JM, Dang TT, Tsai EC, Cao X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials. 2010; 3(6):3714-3728.
Hackett, Joanne M.; Dang, ThucNhi T.; Tsai, Eve C.; Cao, Xudong. 2010. "Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation." Materials 3, no. 6: 3714-3728.