Next Article in Journal / Special Issue
Star-Shaped Conjugated Systems
Previous Article in Journal
A Green Method for Processing Polymers using Dense Gas Technology
Previous Article in Special Issue
Oligomers and Polymers Based on Pentacene Building Blocks
Article Menu

Export Article

Open AccessReview
Materials 2010, 3(5), 3204-3217; doi:10.3390/ma3053204

A Brief Review of Chelators for Radiolabeling Oligomers

Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Author to whom correspondence should be addressed.
Received: 13 March 2010 / Revised: 26 March 2010 / Accepted: 10 May 2010 / Published: 14 May 2010
(This article belongs to the Special Issue Conjugated Oligomers)
View Full-Text   |   Download PDF [368 KB, 27 May 2010; original version 15 May 2010]   |  


The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99mTc, 111In and 188Re. While DNA and its analogs have been radiolabeled with important radionuclides of nonmetals such as 32P, 35S, 14C, 18F and 125I, the labeling methods for these isotopes involve covalent chemistry that is quite distinct from the coordinate-covalent chelation chemistry described herein. In this review, we provide a summary of the several chelators that have been covalently conjugated to oligomers for the purpose of radiolabeling with metallic radionuclides by chelation and including details on the conjugation, the choice of radionuclides and labeling methods.
Keywords: oligomers; DNA analog; chelator; radionuclide oligomers; DNA analog; chelator; radionuclide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, Y.; Liu, G.; Hnatowich, D.J. A Brief Review of Chelators for Radiolabeling Oligomers. Materials 2010, 3, 3204-3217.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top