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A Green Method for Processing Polymers using Dense Gas Technology
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada
School of Chemical Engineering, Chemical Sciences Building, University of New South Wales, Sydney NSW 2052, Australia
* Author to whom correspondence should be addressed.
Received: 29 March 2010; in revised form: 27 April 2010 / Accepted: 6 May 2010 / Published: 11 May 2010
Abstract: Dense CO2 can be used as an environmentally-benign polymer processing medium because of its liquid-like densities and gas-like mass transfer properties.In this work, polymer bio-blends of polycarbonate (PC), a biocompatible polymer, and polycaprolactone (PCL), a biodegradable polymer were prepared. Dense CO2 was used as a reaction medium for the melt-phase PC polymerization in the presence of dense CO2-swollen PCL particles and this method was used to prepare porous PC/PCL blends. To extend the applicability of dense CO2 to the biomedical industry and polymer blend processing, the impregnation of ibuprofen into the blend was conducted and subsequent dissolution characteristics were observed.
Keywords: dense gas technology; polymer processing; green technology; biomedical polymers; drug delivery system; polymer blends; polymerization; polycarbonate; polycaprolactone; ibuprofen
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MDPI and ACS Style
Yoganathan, R.B.; Mammucari, R.; Foster, N.R. A Green Method for Processing Polymers using Dense Gas Technology. Materials 2010, 3, 3188-3203.
Yoganathan RB, Mammucari R, Foster NR. A Green Method for Processing Polymers using Dense Gas Technology. Materials. 2010; 3(5):3188-3203.
Yoganathan, Roshan B.; Mammucari, Raffaella; Foster, Neil R. 2010. "A Green Method for Processing Polymers using Dense Gas Technology." Materials 3, no. 5: 3188-3203.