Materials 2009, 2(4), 1908-1922; doi:10.3390/ma2041908
Article

Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study

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Received: 4 November 2009; in revised form: 17 November 2009 / Accepted: 19 November 2009 / Published: 20 November 2009
(This article belongs to the Special Issue Advances in Biomaterials)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and MersilkTM (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e.g., tissue engineering.
Keywords: spider silk; recombinant; biocompatibility; in vivo
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MDPI and ACS Style

Fredriksson, C.; Hedhammar, M.; Feinstein, R.; Nordling, K.; Kratz, G.; Johansson, J.; Huss, F.; Rising, A. Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study. Materials 2009, 2, 1908-1922.

AMA Style

Fredriksson C, Hedhammar M, Feinstein R, Nordling K, Kratz G, Johansson J, Huss F, Rising A. Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study. Materials. 2009; 2(4):1908-1922.

Chicago/Turabian Style

Fredriksson, Camilla; Hedhammar, My; Feinstein, Ricardo; Nordling, Kerstin; Kratz, Gunnar; Johansson, Jan; Huss, Fredrik; Rising, Anna. 2009. "Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study." Materials 2, no. 4: 1908-1922.

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