Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study
AbstractSpider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and MersilkTM (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e.g., tissue engineering.
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Fredriksson, C.; Hedhammar, M.; Feinstein, R.; Nordling, K.; Kratz, G.; Johansson, J.; Huss, F.; Rising, A. Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study. Materials 2009, 2, 1908-1922.
Fredriksson C, Hedhammar M, Feinstein R, Nordling K, Kratz G, Johansson J, Huss F, Rising A. Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study. Materials. 2009; 2(4):1908-1922.Chicago/Turabian Style
Fredriksson, Camilla; Hedhammar, My; Feinstein, Ricardo; Nordling, Kerstin; Kratz, Gunnar; Johansson, Jan; Huss, Fredrik; Rising, Anna. 2009. "Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study." Materials 2, no. 4: 1908-1922.