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Materials 2018, 11(8), 1339; https://doi.org/10.3390/ma11081339

Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides

1
Key Laboratory of Bio-based Material Science and Technology (Ministry of Education), Northeast Forestry University, Harbin 150040, China
2
College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, China
Authors contributed equally.
*
Author to whom correspondence should be addressed.
Received: 3 June 2018 / Revised: 28 July 2018 / Accepted: 30 July 2018 / Published: 2 August 2018
(This article belongs to the Special Issue Polymeric Materials for Medical Applications)
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Abstract

The agglomeration of silver nanoparticles (AgNPs) results in poor antibacterial performance, and the accumulation of silver in the human body threatens human health. Preparing a matrix is a technique worth considering as it not only prevents the aggregation of AgNPs but also reduces deposition of AgNPs in the human body. In this paper, carboxy-cellulose nanocrystals (CCNC) were prepared by a simple one-step acid hydrolysis method. Chito-oligosaccharides (CSos) were grafted onto the surface of CCNC to form CSos-CCNC composite nanoparticles. CCNC and CSos-CCNC were used as stabilizers for deposing AgNPs and two types of complexes—AgNPs-CCNC and AgNPs-CSos-CCNC—were obtained, respectively. The influence of the two stabilizer matrices—CCNC and CSos-CCNC—on the morphology, thermal behavior, crystal structure, antibacterial activity, and cell compatibility of AgNPs-CCNC and AgNPs-CSos-CCNC were examined. The results showed that the AgNPs deposited on the CSos-CCNC surface had a smaller average diameter and a narrower particle size distribution compared with the ones deposited on CCNC. The thermal stability of AgNPs-CSos-CCNC was better than that of AgNPs-CCNC. AgNPs did not affect the crystalline structure of CCNC and CSos-CCNC. The antibacterial activity of AgNPs-CSos-CCNC was better than that of AgNPs-CCNC based on antibacterial studies using Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. The cytotoxicity of AgNPs-CSos-CCNC was remarkably lower than that of AgNPs-CCNC. View Full-Text
Keywords: carboxy-cellulose nanocrystals; chito-oligosaccharides; silver nanoparticles; antibacterial activity; cytocompatibility carboxy-cellulose nanocrystals; chito-oligosaccharides; silver nanoparticles; antibacterial activity; cytocompatibility
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Ni, X.; Wang, J.; Yue, Y.; Cheng, W.; Wang, D.; Han, G. Enhanced Antibacterial Performance and Cytocompatibility of Silver Nanoparticles Stabilized by Cellulose Nanocrystal Grafted with Chito-Oligosaccharides. Materials 2018, 11, 1339.

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