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Materials 2018, 11(2), 261; doi:10.3390/ma11020261

Application of Polymerization Activator in the Course of Synthesis of N-Isopropylacrylamide Derivatives for Thermally Triggered Release of Naproxen Sodium

Department of Physical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland
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Received: 12 January 2018 / Revised: 31 January 2018 / Accepted: 6 February 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Polymeric Materials for Medical Applications)
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Abstract

Poly-N-isopropylacrylamide (polyNIPA) is an extensively studied polymer in the field of controlled drug delivery. PolyNIPA contains carbonyl and amide groups along a hydrophobic chain. In an aqueous environment, crosslinked polyNIPA forms a gel characterized by a reversible volume phase transition temperature (VPTT), in response to changes in the external environment excited by the temperature factor. NIPA-based polymers were synthesized by a surfactant-free precipitation polymerization (SFPP) method at a temperature of 70 °C using the free radical initiator potassium persulfate (KPS) and at 35 °C using redox initiator system KPS with N,N,N’,N’-tetramethylethylenediamine (TEMED). The synthesized products were evaluated via dynamic light scattering (DLS), nuclear magnetic resonance (NMR) and Fourier-transform infrared spectroscopy (FTIR). The chemical structure, molecular mass, and hydrodynamic diameter of obtained particles, as well as the effects of synthesized polymers on the release of the active substance, naproxen sodium (NS), from hydroxypropyl methyl cellulose (HPMC)-based hydrogels were assessed. The use of the TEMED activator affected the particle size, as well as the release kinetics of NS. The insertion of TEMED into reactant mixtures may be applied to modify the release kinetics of NS from hydrogel preparations. View Full-Text
Keywords: N-isopropylacrylamide; polymer synthesis; thermosensitive hydrogel; drug release; naproxen sodium N-isopropylacrylamide; polymer synthesis; thermosensitive hydrogel; drug release; naproxen sodium
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gasztych, M.; Kotowska, A.; Musiał, W. Application of Polymerization Activator in the Course of Synthesis of N-Isopropylacrylamide Derivatives for Thermally Triggered Release of Naproxen Sodium. Materials 2018, 11, 261.

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