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Materials 2017, 10(7), 726; https://doi.org/10.3390/ma10070726

Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property

1
Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
2
Medical Device Innovation Center, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
3
Department of Materials Science, National University of Tainan, Tainan 700, Taiwan
*
Author to whom correspondence should be addressed.
Received: 18 May 2017 / Revised: 12 June 2017 / Accepted: 28 June 2017 / Published: 30 June 2017
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Abstract

Porous titanium (P_Ti) is considered as an effective material for bone scaffold to achieve a stiffness reduction. Herein, biomimetic (bio-)scaffolds were made of sintered P_Ti, which used NaCl as the space holder and had it removed via the hydrothermal method. X-ray diffraction results showed that the subsequent sintering temperature of 1000 °C was the optimized temperature for preparing P_Ti. The compressive strength of P_Ti was measured using a compression test, which revealed an excellent load-bearing ability of above 70 MPa for that with an addition of 50 wt % NaCl (P_Ti_50). The nano-hardness of P_Ti, tested upon their solid surface, was presumably consistent with the density of pores vis-à-vis the addition of NaCl. Overall, a load-bearable P_Ti with a highly porous structure (e.g., P_Ti_50 with a porosity of 43.91% and a pore size around 340 μm) and considerable compressive strength could be obtained through the current process. Cell proliferation (MTS) and lactate dehydrogenase (LDH) assays showed that all P_Ti samples exhibited high cell affinity and low cell mortality, indicating good biocompatibility. Among them, P_Ti_50 showed relatively good in-cell morphology and viability, and is thus promising as a load-bearable bio-scaffold. View Full-Text
Keywords: porous titanium; biomimetic scaffold; load bearable; cell affinity porous titanium; biomimetic scaffold; load bearable; cell affinity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lee, H.; Liao, J.-D.; Sivashanmugan, K.; Liu, B.H.-C.; Su, Y.-H.; Yao, C.-K.; Juang, Y.-D. Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property. Materials 2017, 10, 726.

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