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Materials 2017, 10(6), 650; doi:10.3390/ma10060650

Synthesis of Au NP@MoS2 Quantum Dots Core@Shell Nanocomposites for SERS Bio-Analysis and Label-Free Bio-Imaging

MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong, China
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Academic Editor: Elisabetta Comini
Received: 13 April 2017 / Revised: 11 May 2017 / Accepted: 26 May 2017 / Published: 13 June 2017
(This article belongs to the Special Issue Ultrathin Two-dimensional (2D) Nanomaterials)
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Abstract

In this work, we report a facile method using MoS2 quantum dots (QDs) as reducers to directly react with HAuCl4 for the synthesis of Au nanoparticle@MoS2 quantum dots (Au NP@MoS2 QDs) core@shell nanocomposites with an ultrathin shell of ca. 1 nm. The prepared Au NP@MoS2 QDs reveal high surface enhanced Raman scattering (SERS) performance regarding sensitivity as well as the satisfactory SERS reproducibility and stability. The limit of detection of the hybrids for crystal violet can reach 0.5 nM with a reasonable linear response range from 0.5 μM to 0.5 nM (R2 ≈ 0.974). Furthermore, the near-infrared SERS detection based on Au NP@MoS2 QDs in living cells is achieved with distinct Raman signals which are clearly assigned to the various cellular components. Meanwhile, the distinguishable SERS images are acquired from the 4T1 cells with the incubation of Au NP@MoS2 QDs. Consequently, the straightforward strategy of using Au NP@MoS2 QDs exhibits great potential as a superior SERS substrate for chemical and biological detection as well as bio-imaging. View Full-Text
Keywords: MoS2 quantum dots; Au nanoparticles; surface enhanced Raman scattering; tumor cells MoS2 quantum dots; Au nanoparticles; surface enhanced Raman scattering; tumor cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fei, X.; Liu, Z.; Hou, Y.; Li, Y.; Yang, G.; Su, C.; Wang, Z.; Zhong, H.; Zhuang, Z.; Guo, Z. Synthesis of Au NP@MoS2 Quantum Dots Core@Shell Nanocomposites for SERS Bio-Analysis and Label-Free Bio-Imaging. Materials 2017, 10, 650.

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