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Materials 2017, 10(6), 581; doi:10.3390/ma10060581

Alizarin Red S-Confined Layer-By-Layer Films as Redox-Active Coatings on Electrodes for the Voltammetric Determination of L-Dopa

1
Faculty of Pharmacy, Takasaki University of Health and Welfare, 37-1 Nakaorui, Takasaki 370-0033, Japan
2
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Reza Montazami
Received: 24 March 2017 / Revised: 23 May 2017 / Accepted: 23 May 2017 / Published: 25 May 2017
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Abstract

The preparation of redox-active coatings is a key step in fabricating electrochemical biosensors. To this goal, a variety of coating materials have been used in combination with redox-active compounds. In this study, alizarin red S (ARS) was confined in layer-by-layer (LbL) films composed of poly(ethyleneimine) (PEI) and carboxymethylcellulose (CMC) to study the redox properties. A gold (Au) disc electrode coated with PEI/CMC LbL film was immersed in an ARS solution to uptake ARS into the film. ARS was successfully confined in the LbL film through electrostatic interactions. The cyclic voltammogram (CV) of ARS-confined PEI/CMC film-coated electrodes thus prepared exhibited redox waves in the potential range from −0.5 to −0.7 V originating from 9,10-anthraquinone moiety in ARS, demonstrating that ARS preserves its redox activity in the LbL film. An additional oxidation peak appeared around −0.4 V in the CV recorded in the solution containing phenylboronic acid (PBA), due to the formation of a boronate ester of ARS (ARS-PBA) in the film. The oxidation peak current at −0.4 V decreased upon addition of 3,4-dihydroxyphenylalanine (L-dopa) to the solution. Thus, the results suggest a potential use of the ARS-confined PEI/CMC films for constructing voltammetric sensors for L-dopa. View Full-Text
Keywords: layer-by-layer film; electrode; voltammetry; alizarin red S; L-dopa layer-by-layer film; electrode; voltammetry; alizarin red S; L-dopa
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Takahashi, S.; Suzuki, I.; Sugawara, T.; Seno, M.; Minaki, D.; Anzai, J.-I. Alizarin Red S-Confined Layer-By-Layer Films as Redox-Active Coatings on Electrodes for the Voltammetric Determination of L-Dopa. Materials 2017, 10, 581.

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