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Materials 2017, 10(4), 431; doi:10.3390/ma10040431

Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm

1
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
2
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
3
Department of Preventive Dentistry, Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China
4
Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Juergen Stampfl
Received: 29 December 2016 / Revised: 14 April 2017 / Accepted: 14 April 2017 / Published: 20 April 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [9417 KB, uploaded 20 April 2017]   |  

Abstract

The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin. The specimens were incubated with C. albicans solution in medium to form biofilms. Then Colony-Forming Units, XTT assay, and scanning electron microscope were used to evaluate antifungal effect of DMADDM-modified resin. DMADDM modified acrylic resin had no effect on the flexural strength, bond quality, and surface roughness, but it increased the surface charge density significantly. Meanwhile, this new resin inhibited the C. albicans biofilm significantly according to the XTT assay and CFU counting. The hyphae in C. albicans biofilm also reduced in DMADDM-containing groups observed by SEM. DMADDM modified acrylic resin was effective in the inhibition of C. albicans biofilm with good physical properties. View Full-Text
Keywords: heat-polymerized resin; dimethylaminododecyl methacrylate; Candida albicans biofilms; denture stomatitis; antifungal properties. heat-polymerized resin; dimethylaminododecyl methacrylate; Candida albicans biofilms; denture stomatitis; antifungal properties.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, H.; Han, Q.; Zhou, X.; Zhang, K.; Wang, S.; Xu, H.H.K.; Weir, M.D.; Feng, M.; Li, M.; Peng, X.; Ren, B.; Cheng, L. Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm. Materials 2017, 10, 431.

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