Next Article in Journal
Nanocomposite Based on Functionalized Gold Nanoparticles and Sulfonated Poly(ether ether ketone) Membranes: Synthesis and Characterization
Previous Article in Journal
Influence of Ultrasound Treatment on Cavitation Erosion Resistance of AlSi7 Alloy
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Materials 2017, 10(3), 257; doi:10.3390/ma10030257

Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration

1
Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
2
Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
3
VIP Integrated Department, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
4
Department of Oral Mucositis, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 17 January 2017 / Revised: 20 February 2017 / Accepted: 27 February 2017 / Published: 3 March 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [5760 KB, uploaded 3 March 2017]   |  

Abstract

Guided bone regeneration (GBR) is one such treatment that reconstructs neo-bone tissue by using a barrier membrane to prevent the invasion of soft tissue and to create a space for guiding new bone growth into the bone defect. Herein, we report a novel functionally graded bilayer membrane (FGBM) for GBR application. To fabricate the novel membrane, the composites of poly(lactic-co-glycolic acid) and nano-hydroxyapatite were prepared by phase inversion for the dense layer and by electrospinning for another porous layer, and their corresponding properties were evaluated including surface morphology, mechanics, degradability, cell barrier function, and in vitro osteogenic bioactivity. The results showed that PLGA with 5% nHA in dense layer could meet the requirement of mechanical strength and have excellent barrier function even on condition of post-degradation. Furthermore, PLGA with 30% nHA in porous layer could achieve the good physical and chemical properties. In addition, 30% nHA incorporation would enhance the in vitro mineralization, and have superior capabilities of cell adhesion, proliferation and differentiation compared to other groups. Therefore, the designed FGBM could potentially serve as a barrier for preferential tissue ingrowth and achieve a desirable therapeutic result for bone tissue regeneration. View Full-Text
Keywords: GBR membrane; poly(lactic-co-glycolic acid); nano-hydroxyapatite; barrier function; osteogenesis; osteoblast GBR membrane; poly(lactic-co-glycolic acid); nano-hydroxyapatite; barrier function; osteogenesis; osteoblast
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fu, L.; Wang, Z.; Dong, S.; Cai, Y.; Ni, Y.; Zhang, T.; Wang, L.; Zhou, Y. Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration. Materials 2017, 10, 257.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top