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Materials 2017, 10(12), 1417; https://doi.org/10.3390/ma10121417

Silk Materials Functionalized via Genetic Engineering for Biomedical Applications

1
Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 61-688 Poznan, Poland
2
Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 61-688 Poznan, Poland
*
Author to whom correspondence should be addressed.
Received: 6 November 2017 / Revised: 4 December 2017 / Accepted: 6 December 2017 / Published: 12 December 2017
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Abstract

The great mechanical properties, biocompatibility and biodegradability of silk-based materials make them applicable to the biomedical field. Genetic engineering enables the construction of synthetic equivalents of natural silks. Knowledge about the relationship between the structure and function of silk proteins enables the design of bioengineered silks that can serve as the foundation of new biomaterials. Furthermore, in order to better address the needs of modern biomedicine, genetic engineering can be used to obtain silk-based materials with new functionalities. Sequences encoding new peptides or domains can be added to the sequences encoding the silk proteins. The expression of one cDNA fragment indicates that each silk molecule is related to a functional fragment. This review summarizes the proposed genetic functionalization of silk-based materials that can be potentially useful for biomedical applications. View Full-Text
Keywords: bioengineered silk; biomaterials; functionalization; genetic engineering; biomedicine bioengineered silk; biomaterials; functionalization; genetic engineering; biomedicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Deptuch, T.; Dams-Kozlowska, H. Silk Materials Functionalized via Genetic Engineering for Biomedical Applications. Materials 2017, 10, 1417.

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