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Materials 2017, 10(11), 1274; doi:10.3390/ma10111274

In Vitro Degradation of Borosilicate Bioactive Glass and Poly(l-lactide-co-ε-caprolactone) Composite Scaffolds

BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Korkeakoulunkatu 3, 33720 Tampere, Finland
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Received: 26 September 2017 / Revised: 30 October 2017 / Accepted: 1 November 2017 / Published: 6 November 2017
(This article belongs to the Special Issue Bioactive Glasses 2017)
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Abstract

Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO2. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a function of immersion time, the solution pH increased due to the glass dissolution. This was further supported by the increasing amount of Ca in the immersing solution with increasing immersion time and glass content. Furthermore, the change in scaffold mass was significantly greater with increasing the glass content in the scaffold. However, only the scaffolds containing 30 and 50 wt % of glasses exhibited significant hydroxyapatite (HA) formation at 72 h of immersion. The compression strength of the samples was also measured. The Young’s modulus was similar for the 10 and 30 wt % glass-containing scaffolds whereas it increased to 90 MPa for the 50 wt % glass containing scaffold. Upon immersion up to 72 h, the Young’s modulus increased and then remained constant for longer immersion times. The scaffold prepared could have great potential for bone and cartilage regeneration. View Full-Text
Keywords: bioactive glass; PLCL copolymer; composite; scaffolds; hydroxyapatite bioactive glass; PLCL copolymer; composite; scaffolds; hydroxyapatite
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MDPI and ACS Style

Tainio, J.; Paakinaho, K.; Ahola, N.; Hannula, M.; Hyttinen, J.; Kellomäki, M.; Massera, J. In Vitro Degradation of Borosilicate Bioactive Glass and Poly(l-lactide-co-ε-caprolactone) Composite Scaffolds. Materials 2017, 10, 1274.

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