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Special Issue "Bioactive Glasses 2017"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 31 December 2017

Special Issue Editors

Guest Editor
Dr. Francesco Baino

Department of Applied Science and Technology, Politecnico di Torino (Italy)
Website | E-Mail
Interests: biomaterials; bioactive glasses; bioceramics; composite materials; tissue engineering; porous materials
Guest Editor
Prof. Aldo R. Boccaccini

Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany; Visiting Professor, Department of Materials, Imperial College London, London SW7 2BP, UK
Website | E-Mail
Fax: +49 9131 85 28602
Interests: biomaterials; porous materials; scaffolds; tissue engineering; bioactive glasses; composite materials; waste recycling; carbon nanotubes; electrophoretic deposition; vascularization; bioceramics; biofabrication; bioactive coatings; drug delivery
Guest Editor
Prof. Enrica Verné

Department of Applied Science and Technology, Politecnico di Torino (Italy)
Website | E-Mail
Interests: biomaterials; bioactive glasses; antibacterial materials; surface functionalization; magnetic materials; nanomaterials

Special Issue Information

Dear Colleagues,

For centuries, glass has played an important role in the practical and aesthetic aspects of our lives and culture. Some special types of glass have revolutionized medicine since Larry Hench invented 45S5 Bioglass®, almost 50 years ago, at the University of Florida. This material was the first able to bond to bone, forming a tight interface, and launched our modern idea of biomaterials science. Many other bioactive glass compositions have been developed over the years, which have controllable degradation rates, so that glass implant dissolution can be closely matched to the rate of new bone formation. Bioactive glasses can be doped with trace quantities of metal elements that, once released, are known to be beneficial for healthy bone growth (e.g., Sr) or to elicit a therapeutic effect, such as antibacterial properties (e.g., Ag).

Recent advances in biomaterials processing have led to the creation of functional coatings, 3D porous scaffolds, fibrous constructs, and moldable implants with a range of mechanical properties suitable for the repair of both load-bearing and non-loaded bone. Furthermore, emerging applications of bioactive glasses in contact with soft tissues are increasingly attracting the interest of researchers. Recent work has shown the ability of bioactive glasses to promote angiogenesis, which is a critical requirement for promoting both bone and soft tissue regeneration, such as wound healing. Surface functionalization and incorporation in composite biomaterials are valuable strategies to develop bioactive glass-based systems for the local delivery of drugs and therapeutic biomolecules, which are key for the treatment of a number of diseases ranging from chronic infections to malignant tumors.

In summary, new and continuous advances in bioactive glass processing technologies and novel applications of biomedical glasses in tissue engineering and advanced therapy bring further honor to the long history of glass in medicine and open unexpected scenarios for patient’s treatment and rehabilitation.

It is, therefore, our immense pleasure to invite you to submit a manuscript for the Special Issue, “Bioactive Glasses 2017”. Full research articles, short communications and comprehensive review papers covering all aspects of design, processing, characterization, modelling and applications of bioactive glasses are welcome.

Francesco Baino
Aldo R. Boccaccini
Enrica Verné
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive glasses
  • Silicate glasses
  • Borate glasses
  • Phosphate glasses
  • Composites
  • Hybrids
  • Bioactivity
  • Scaffolds
  • Coatings
  • Additive manufacturing
  • Surface functionalization
  • Modelling
  • Tissue engineering
  • Drug delivery
  • Ion release

Published Papers (1 paper)

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Research

Open AccessFeature PaperArticle In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass
Materials 2017, 10(7), 740; doi:10.3390/ma10070740
Received: 1 June 2017 / Revised: 24 June 2017 / Accepted: 29 June 2017 / Published: 3 July 2017
PDF Full-text (2136 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from
[...] Read more.
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5, in which Na2O was partially substituted by 5% Li2O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
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