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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">ijerph</journal-id>
      <journal-title>International Journal of Environmental Research and Public Health</journal-title>
      <abbrev-journal-title abbrev-type="publisher">Int. J. Environ. Res. Public Health</abbrev-journal-title>
      <abbrev-journal-title abbrev-type="pubmed">International journal of environmental research and public health</abbrev-journal-title>
      <issn pub-type="epub">1660-4601</issn>
      <publisher>
        <publisher-name>MDPI</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.3390/ijerph9030722</article-id>
      <article-id pub-id-type="publisher-id">ijerph-09-00722</article-id>
      <article-categories>
        <subj-group>
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A Systematic Review of Social Factors and Suicidal Behavior in Older Adulthood</article-title>
      </title-group>
      
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Fässberg</surname>
            <given-names>Madeleine Mellqvist</given-names>
          </name>
          <xref rid="af1-ijerph-09-00722" ref-type="aff">1</xref>
          <xref rid="fn1-ijerph-09-00722" ref-type="fn">†</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>van Orden</surname>
            <given-names>Kimberly A.</given-names>
          </name>
          <xref rid="af2-ijerph-09-00722" ref-type="aff">2</xref>
          <xref rid="fn1-ijerph-09-00722" ref-type="fn">†</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Duberstein</surname>
            <given-names>Paul</given-names>
          </name>
          <xref rid="af2-ijerph-09-00722" ref-type="aff">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Erlangsen</surname>
            <given-names>Annette</given-names>
          </name>
          <xref rid="af3-ijerph-09-00722" ref-type="aff">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Lapierre</surname>
            <given-names>Sylvie</given-names>
          </name>
          <xref rid="af4-ijerph-09-00722" ref-type="aff">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bodner</surname>
            <given-names>Ehud</given-names>
          </name>
          <xref rid="af5-ijerph-09-00722" ref-type="aff">5</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Canetto</surname>
            <given-names>Silvia Sara</given-names>
          </name>
          <xref rid="af6-ijerph-09-00722" ref-type="aff">6</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Leo</surname>
            <given-names>Diego De</given-names>
          </name>
          <xref rid="af7-ijerph-09-00722" ref-type="aff">7</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Szanto</surname>
            <given-names>Katalin</given-names>
          </name>
          <xref rid="af8-ijerph-09-00722" ref-type="aff">8</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Waern</surname>
            <given-names>Margda</given-names>
          </name>
          <xref rid="af9-ijerph-09-00722" ref-type="aff">9</xref>
          <xref rid="c1-ijerph-09-00722" ref-type="corresp">*</xref>
        </contrib>
      </contrib-group>
      <aff id="af1-ijerph-09-00722"><label>1</label> Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Wallinsgatan 6, 43141 Mölndal, Sweden; Email: <email>madeleine.mellqvist@neuro.gu.se</email></aff>
      <aff id="af2-ijerph-09-00722"><label>2</label> Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA; Email: <email>Kimberly_Vanorden@URMC.Rochester.edu</email> (K.A.O.); <email>Paul_Duberstein@URMC.Rochester.edu</email> (P.D.)</aff>
      <aff id="af3-ijerph-09-00722"><label>3</label> Department of Mental Health, Johns Hopkins School of Public Health, 624 North Broadway, S850, Baltimore, MD 21205, USA; Email: <email>aerlangs@jhsph.edu</email></aff>
      <aff id="af4-ijerph-09-00722"><label>4</label> Département de Psychologie, Université du Québec à Trois-Rivières, 3351 des Forges blvd., Trois-Rivières, QC G9A 5H7, Canada; Email: <email>Sylvie.Lapierre@uqtr.ca</email></aff>
      <aff id="af5-ijerph-09-00722"><label>5</label> The Interdisciplinary Department of Social Sciences and the Music Department, Bar-Ilan University, Ramat-Gan, Israel; Email: <email>Ehud.Bodner@biu.ac.il</email></aff>
      <aff id="af6-ijerph-09-00722"><label>6</label> Department of Psychology, Colorado State University, Fort Collins, CO 80523, USA; Email: <email>Silvia.Canetto@colostate.edu</email></aff>
      <aff id="af7-ijerph-09-00722"><label>7</label> Australian Institute for Suicide Research and Prevention, National Centre of Excellence in Suicide Prevention, WHO Collaborating Centre for Research and Training in Suicide Prevention, and Life Promotion Clinic, Mt Gravatt Campus, Griffith University,176 Messines Ridge Road, Mt Gravatt, QLD 4122, Australia; Email: <email>d.deleo@griffith.edu.au</email></aff>
      <aff id="af8-ijerph-09-00722"><label>8</label> Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O’Hara Street, Pittsburgh, PA 15260, USA; Email: <email>SzantoK@upmc.edu</email></aff>
      <aff id="af9-ijerph-09-00722"><label>9</label> Department of Psychiatry and Neurochemistry, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Blå Stråket 15, 41345 Gothenburg, Sweden</aff>
      <author-notes>
        <fn id="fn1-ijerph-09-00722">
          <label>†</label>
          <p>These authors contributed equally to this work.</p>
        </fn>
        <corresp id="c1-ijerph-09-00722"><label>*</label> Author  to whom correspondence should be addressed; Email: <email>margda.waern@neuro.gu.se</email>; Tel.: +46-702-272-205; Fax: +46-31-828-163.</corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>01</day>
        <month>03</month>
        <year>2012</year>
      </pub-date>
      <pub-date pub-type="ppub">
        <month>03</month>
        <year>2012</year>
      </pub-date>
      <volume>9</volume>
      <issue>3</issue>
      <fpage>722</fpage>
      <lpage>745</lpage>
      <history>
        <date date-type="received">
          <day>26</day>
          <month>01</month>
          <year>2012</year>
        </date>
        <date date-type="rev-recd">
          <day>16</day>
          <month>02</month>
          <year>2012</year>
        </date>
        <date date-type="accepted">
          <day>22</day>
          <month>02</month>
          <year>2012</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© 2012 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
        <copyright-year>2012</copyright-year>
        <license xmlns:xlink="http://www.w3.org/1999/xlink" license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/">
          <p>This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).</p>
        </license>
      </permissions>
      <abstract>
        <p>Suicide in later life is a global public health problem. The aim of this review was to conduct a systematic analysis of studies with comparison groups that examined the associations between social factors and suicidal behavior (including ideation, non-fatal suicidal behavior, or deaths) among individuals aged 65 and older. Our search identified only 16 articles (across 14 independent samples) that met inclusion criteria. The limited number of studies points to the need for further research. Included studies were conducted in Canada (n = 2), Germany (n = 1), Hong Kong (n = 1), Japan (n = 1), Singapore (n = 1), Sweden (n = 2), Taiwan (n = 1), the U.K. (n = 2), and the U.S. (n = 3). The majority of the social factors examined in this review can be conceptualized as indices of positive social connectedness—the degree of positive involvement with family, friends, and social groups. Findings indicated that at least in industrialized countries, limited social connectedness is associated with suicidal ideation, non-fatal suicidal behavior, and suicide in later life. Primary prevention programs designed to enhance social connections as well as a sense of community could potentially decrease suicide risk, especially among men.</p>
      </abstract>
      <kwd-group>
        <kwd>death wishes</kwd>
        <kwd>suicidal ideation</kwd>
        <kwd>non-fatal suicidal behavior</kwd>
        <kwd>suicide</kwd>
        <kwd>social factors</kwd>
        <kwd>social support</kwd>
        <kwd>systematic review</kwd>
        <kwd>older adults</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro">
      <title>1. Introduction</title>
      <p>Suicide in later life is a global public health problem, with those aged 65 and above constituting the demographic group with the highest suicide rate in most countries that report suicide statistics to the World Health Organization [<xref ref-type="bibr" rid="B1-ijerph-09-00722">1</xref>]. Countries with high rates of older adult suicide include European Union countries, Canada, the U.S., and several Asian countries, including Japan, Singapore, and Taiwan. Older men are at particularly elevated risk in these countries [<xref ref-type="bibr" rid="B1-ijerph-09-00722">1</xref>,<xref ref-type="bibr" rid="B2-ijerph-09-00722">2</xref>], with the gender gap in suicide mortality less pronounced in Asian countries [<xref ref-type="bibr" rid="B3-ijerph-09-00722">3</xref>]. Prevention of late-life suicide is marked by numerous challenges. First and foremost, in many countries older adult suicidal behavior is highly lethal [<xref ref-type="bibr" rid="B2-ijerph-09-00722">2</xref>]. Non-fatal suicidal acts tend to be less common in this age group [<xref ref-type="bibr" rid="B4-ijerph-09-00722">4</xref>]. For example, in the U.S., up to 75% of older adults die as a consequence of their first suicidal act [<xref ref-type="bibr" rid="B5-ijerph-09-00722">5</xref>], which may be explained by age-related increases in planning [<xref ref-type="bibr" rid="B6-ijerph-09-00722">6</xref>], physical frailty and method lethality [<xref ref-type="bibr" rid="B7-ijerph-09-00722">7</xref>]. Further, U.S. older persons are less likely to report thoughts of suicide to others [<xref ref-type="bibr" rid="B8-ijerph-09-00722">8</xref>] and to use mental health services [<xref ref-type="bibr" rid="B9-ijerph-09-00722">9</xref>,<xref ref-type="bibr" rid="B10-ijerph-09-00722">10</xref>]. Thus, interventions are needed to prevent suicidal behavior also among those with no prior history of suicidal behavior and those who do not seek psychiatric treatment. </p>
      <p>Psychological autopsy studies (in which detailed psychiatric, medical and psychosocial histories are obtained for individuals who died by suicide via structured interviews with family and others who knew the individuals well) indicate that mental disorder is present in 71–97% of older adults who die by suicide with depression as the most common diagnosis [<xref ref-type="bibr" rid="B2-ijerph-09-00722">2</xref>]. A U.S.-based study demonstrated that depression is a particularly strong correlate of suicide in later life [<xref ref-type="bibr" rid="B11-ijerph-09-00722">11</xref>]. Thoughts of suicide become less prominent or frequent when depression remits in older persons who are treated for depression [<xref ref-type="bibr" rid="B12-ijerph-09-00722">12</xref>]. Preventing or treating depression could thus constitute powerful suicide prevention strategies for this age group. The possible preventive role of depression screening and follow-up was highlighted via a meta-analysis of quasi-experimental studies of older adults in several Japanese regions. Reduced suicide rates were observed in the intervention regions, particularly in women [<xref ref-type="bibr" rid="B13-ijerph-09-00722">13</xref>]. Collaborative care models (CCM) for depression which involve augmenting depression treatment in primary care with expert mental health consultation and medication recommendations, psychoeducation for patients, and the option of brief psychotherapy have been shown to reduce suicide ideation among older adults in the U.S. [<xref ref-type="bibr" rid="B14-ijerph-09-00722">14</xref>,<xref ref-type="bibr" rid="B15-ijerph-09-00722">15</xref>]. However, suicide ideation may persist following treatment in some individuals. Further, decreases in the frequency or severity of thoughts about suicide do not necessarily indicate reduced suicide risk. Most depressed people do not die by suicide, and there are modifiable risk markers for both depression and suicide that can be targeted before the emergence of depression, suicidal feelings, and other risk factors for suicide mortality. Social factors can constitute important targets in this context. </p>
      <p>The influential role of social factors in the etiology of suicide was highlighted by Durkheim [<xref ref-type="bibr" rid="B16-ijerph-09-00722">16</xref>], whose model of suicide focuses on two social forces, social integration and moral integration. According to Durkheim, changes in suicide rates at the societal level will occur when these forces become dysregulated (<italic>i.e.</italic>, too strong or too weak). Specifically, too much or too little social integration as well as too much or too little moral integration should be associated with increased suicide rates according to Durkheim, due to the emergence of subtypes of suicide, each with a distinct social factor underlying the etiology. In the case of too much social integration, Durkheim proposed that “altruistic” suicides result because members of society become willing to sacrifice themselves for the larger good. Regarding too little social integration, Durkheim proposed that “egoistic” suicides result because members of society do not feel connected to their society—to something that transcends their individual experiences and provides an existential anchor. In the case of too much moral integration Durkheim proposed that “fatalistic” suicides result because members of society experience a total lack of autonomy due to societal over-regulation of beliefs and behaviors through such factors as social norms or the justice system). Regarding too little moral integration, Durkheim proposed that “anomic” suicides result because members of society lack a sense of security and structure. </p>
      <p>Psychological theorists have also proposed causal roles for social factors, but in contrast to sociological theorists (e.g., Durkheim), they emphasize connections at the individual level, rather than connections with society. Most of these theories focus on familial relationships. Feeling isolated from family members, experiencing family discord, and perceiving oneself to be a burden on family members are all social factors posited by psychological theorists to be involved in the etiology of suicide [<xref ref-type="bibr" rid="B17-ijerph-09-00722">17</xref>,<xref ref-type="bibr" rid="B18-ijerph-09-00722">18</xref>]. One psychological theory that does not specifically focus on the family is the Interpersonal Theory of Suicide [<xref ref-type="bibr" rid="B16-ijerph-09-00722">16</xref>], which proposes that individuals have a psychological need to feel connected to and cared about by others, termed the need to belong, and that when this need is completely unmet, a passive desire for death will develop. The theory also posits that when individuals perceive that they are a burden on others (regardless of the veracity of the belief) such that others would be better off if they were gone, a passive desire for death will develop. Further, the theory specifies that when the need to belong is unmet and perceptions of burdensomeness are present, a passive desire for death will transform into active thoughts of killing oneself. Finally, the Interpersonal Theory also proposes that social factors are not sufficient to explain suicide. Other psychological factors are needed to explain why the vast majority of those who think about suicide do not actually harm themselves. The theory proposes that this is the case because most individuals are not capable of suicide, and to be capable, individuals must lose some of the fear associated with suicidal behavior and be able to tolerate the pain that accompanies suicidal behavior. </p>
      <p>Common themes from these diverse theorists are that positive social connections may be protective against suicide, whereas discordant or overly strong/enmeshed connections may elevate risk for suicide. Another theme is that social factors alone are insufficient to explain the etiology of suicidal behavior. Rather, these social factors interact with characteristics of individuals to influence the risk for suicide. The social context is a crucial factor in understanding risk for suicide [<xref ref-type="bibr" rid="B19-ijerph-09-00722">19</xref>] and to make sense of the overwhelmingly high rates of suicide in older males, especially in U.S., Canada and many European countries [<xref ref-type="bibr" rid="B20-ijerph-09-00722">20</xref>]. In fact, the only randomized intervention trials with evidence suggesting a reduction of suicides, though not conducted specifically with older adults, have been posited to work by enabling at-risk individuals to feel more connected to others and cared for [<xref ref-type="bibr" rid="B21-ijerph-09-00722">21</xref>,<xref ref-type="bibr" rid="B22-ijerph-09-00722">22</xref>]. There are several quasi-experimental studies of interventions designed to increase social connectedness (<italic>i.e.</italic>, the degree to which older adults are connected to family, friends, and their communities) with results suggesting that this is a promising strategy for reducing late-life suicide rates [<xref ref-type="bibr" rid="B13-ijerph-09-00722">13</xref>,<xref ref-type="bibr" rid="B23-ijerph-09-00722">23</xref>,<xref ref-type="bibr" rid="B24-ijerph-09-00722">24</xref>]. While a role for social factors has been indicated in several reviews on suicide in later life [<xref ref-type="bibr" rid="B2-ijerph-09-00722">2</xref>,<xref ref-type="bibr" rid="B25-ijerph-09-00722">25</xref>], we are aware of no systematic review focusing specifically on social factors and suicidal behavior in this age group. Thus, the aim of this review was to identify social factors that are robustly associated with suicide and related phenomena among persons aged 65 and above. This review will address the following questions:</p>
      <list list-type="simple">
        <list-item>
          <p>(1) Which social factors are associated with death wishes, suicide ideation, non-fatal suicidal behavior, and/or suicides in later life?</p>
        </list-item>
        <list-item>
          <p>(2) What are areas in need of future research on social factors in late-life suicidal behavior?</p>
        </list-item>
        <list-item>
          <p>(3) What are the implications for the prevention of suicidal behavior in this age group?</p>
        </list-item>
      </list>
    </sec>
    <sec>
      <title>2. Method</title>
      <p>Guidelines from the Cochrane Collaboration were used for this systematic review [<xref ref-type="bibr" rid="B26-ijerph-09-00722">26</xref>]. Case-comparison studies that focused on persons aged 65 years and above, published in peer-reviewed journals, and examining both social factors and suicide or related phenomenon (death wishes, suicide ideation, deliberate self harm/non-fatal suicidal behavior) were considered eligible for inclusion. For the purpose of this review, we chose to focus on social factors related to social connectedness and social inclusion. </p>
      <p>Studies were identified through electronic searches which were performed through the ERIC, Scopus, SUMMON, PubMed, and PsycINFO databases. Search terms used were: suicid* OR death wishes OR deliberate self harm. No search terms relating to social factors were applied. All publication years were considered. The search was carried out during August–September 2011.</p>
      <p>The combined searches yielded 23,299 references. Where a title or an abstract appeared to describe a study that included older persons and data on both social factors and suicidal behavior, the full article was retrieved and examined for relevance. Studies lacking similar age comparison groups were excluded as were those involving persons under age 65. Further, articles written in languages other than English were excluded. Only 16 publications met the inclusion criteria, and these publications were based on data from a total of 14 studies. Associations confirmed in multivariate analyses were preferred over univariate. </p>
    </sec>
    <sec sec-type="results">
      <title>3. Results</title>
      <p>Findings of the review are shown by social factor in <xref ref-type="table" rid="ijerph-09-00722-t001">Table 1</xref> and summarized in box score format in <xref ref-type="table" rid="ijerph-09-00722-t002">Table 2</xref>. Seven studies (with eight publications) focused on death wishes/suicide ideation [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>,<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>,<xref ref-type="bibr" rid="B29-ijerph-09-00722">29</xref>,<xref ref-type="bibr" rid="B30-ijerph-09-00722">30</xref>,<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>,<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>,<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>,<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]. Factors related to self-harm/non-fatal suicidal behavior were examined in six studies [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>,<xref ref-type="bibr" rid="B35-ijerph-09-00722">35</xref>,<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>,<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>,<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>,<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. Only three studies (with four publications) examined suicide/fatal suicidal behavior [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>,<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>,<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>,<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]. </p>
      <p><italic>Marital status</italic> was examined in eleven studies. Not having a current partner was associated with death wishes in a Canadian community-based study by Lapierre [<xref ref-type="bibr" rid="B30-ijerph-09-00722">30</xref>]. Bartels studied correlates of passive death ideation and active suicide ideation in over 2,000 U.S. primary care patients with depression, anxiety or problematic alcohol use [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]; no association was found with marital status. In a clinical study set in Singapore, Tan found that marital status did not distinguish depressed patients with and without suicidal ideation [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]. Similarly, no association with marital status was observed in a U.S. study conducted by Raue which examined suicidal ideation (passive/active/none) in recipients of in-home nursing [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>]. Yen reported that being single or widowed was associated with suicidal ideation in community dwelling older persons in a study from Taiwan [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]. Marital status did not differ in persons who reported death wishes/suicidal thoughts/non-fatal suicidal behavior compared to those without death wishes in Barnow’s population-based study set in Germany [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>]. A Swedish study conducted by Wiktorsson focused on individuals aged 70 and above who were hospitalized in connection with a suicide attempt and a population-based comparison group [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. Those who were treated in connection with a suicide attempt were more likely to be unmarried/not cohabitating. No such relationship was found in a Japanese study by Takahashi [<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>], nor in Tsoh’s study that was set in Hong Kong [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]. In a Scotland-based study, Conaghan observed that persons who were hospitalized in connection with a non-fatal suicidal act were statistically significantly <italic>more often</italic> married than those in the community-based comparison group [<xref ref-type="bibr" rid="B35-ijerph-09-00722">35</xref>]. Finally, Turvey presented data from a prospective U.S. population-based study showing no association between marital status and suicide [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]. </p>
      <p><italic>Living arrangement</italic> was examined in most of the studies included in this review. Results were mixed. Regarding <italic>living alone</italic>, no association was seen with death ideation in the Bartels study [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]. Further, no relationship was observed with suicide ideation in that study, which was also the case in the study by Raue [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>], and the Yen study from Taiwan [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>].</p>
      <p>No difference in proportions living alone could be shown in a British study by Dennis that compared a self-harm group and a depressed comparison group [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>]. However, in a clinical study set in Japan, Takahashi found that persons with a history of suicidal behavior more often lived alone than other psychiatric inpatients [<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>]. Living alone was associated with increased risk of suicide attempt in the Swedish study conducted by Wiktorsson [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. No such association was found, however in the Rubenowitz study that focused on suicide in the same region [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>] and similar results were observed for men and women. Data from that study were examined further by Waern, who carried out separate analyses for younger (65–74 years) and older (75+) age groups and found no difference between the two groups with regards to living alone [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>].</p>
      <table-wrap id="ijerph-09-00722-t001" position="anchor">
        <object-id pub-id-type="pii">ijerph-09-00722-t001_Table 1</object-id>
        <label>Table 1</label>
        <caption>
          <p>Review findings summarized by social factor.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th align="left" valign="middle">Social factor</th>
              <th align="left" valign="middle">Authors</th>
              <th align="left" valign="middle">Study type</th>
              <th align="left" valign="middle">Country</th>
              <th align="left" valign="middle">Subjects</th>
              <th align="left" valign="middle">Outcome</th>
              <th align="left" valign="middle">Measure of social factor</th>
              <th align="left" valign="middle">Strength of association</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="middle">Marital status</td>
              <td align="left" valign="middle">Lapierre <italic>et al.</italic> (2011) [<xref ref-type="bibr" rid="B30-ijerph-09-00722">30</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Canada</td>
              <td align="left" valign="middle">Community dwellers <sup>C</sup></td>
              <td align="left" valign="middle">Wish to die</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">No current partner <italic>vs.</italic> married: OR = 1.9 (95% CI = 1.3–2.9)<sup> ii</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Bartels <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Primary care patients with depression <sup>C</sup></td>
              <td align="left" valign="middle">Death ideation/Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tan <italic>et al.</italic> (2008) [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Singapore</td>
              <td align="left" valign="middle">Patients with major depression <sup>A</sup></td>
              <td align="left" valign="middle">Suicidal thinking</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Raue <italic>et al.</italic> (2007) [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Homecare patients <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Yen <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Taiwan</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Single/widowed <italic>vs.</italic> married: OR = 2.04 (95% CI = 1.25–3.31) <sup>iii</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Barnow <italic>et al.</italic> (2004) [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Germany</td>
              <td align="left" valign="middle">Community dwellers 70+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide thoughts/attempts</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Wiktorsson <italic>et al.</italic> (2010) [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Sweden</td>
              <td align="left" valign="middle">Population 70+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Married/Cohabiting <italic>vs.</italic> not: OR = 0.51 (95% CI = 0.31–0.84)</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Takahashi <italic>et al.</italic> (1995) [<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Japan</td>
              <td align="left" valign="middle">Psychiatric inpatients <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tsoh <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]</td>
              <td align="left" valign="middle">Nested-Clinical</td>
              <td align="left" valign="middle">Hong Kong</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt/suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Conaghan <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B35-ijerph-09-00722">35</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">UK</td>
              <td align="left" valign="middle">Psychiatric patients and community dwellers <sup>A</sup></td>
              <td align="left" valign="middle">Parasuicide/depression</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Married <italic>vs.</italic> unmarried/widowed: Fisher’s exact = 10.47, <italic>p</italic> &lt; 0.005</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Turvey <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Marital status: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle">Living arrangement</td>
              <td align="left" valign="middle">Bartels <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Primary care patients with depression <sup>C</sup></td>
              <td align="left" valign="middle">Death ideation/Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone <italic>vs.</italic> living with someone: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Raue <italic>et al.</italic> (2007) [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Homecare patients <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living arrangement: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Yen <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Taiwan</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Not living alone <italic>vs.</italic> living alone: NS <sup>iii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Dennis <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">UK</td>
              <td align="left" valign="middle">Participants with depression <sup>A</sup></td>
              <td align="left" valign="middle">Self harm behavior</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Takahashi <italic>et al.</italic> (1995) [<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Japan</td>
              <td align="left" valign="middle">Psychiatric inpatients <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone: <italic>p</italic> &lt; 0.01</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Wiktorsson <italic>et al.</italic> (2010) [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Sweden</td>
              <td align="left" valign="middle">Population 70+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone <italic>vs.</italic> not: OR = 1.90 (95% CI = 1.16–3.11); Living in institution <italic>vs.</italic> not: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Rubenowitz <italic>et al.</italic> (2001) [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]</td>
              <td align="left" valign="middle">Psychological autopsy</td>
              <td align="left" valign="middle">Sweden</td>
              <td align="left" valign="middle">Community dwellers B</td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone <italic>vs.</italic> not—by sex: NS <sup>ii</sup></td>
            </tr>
            <tr>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Waern <italic>et al.</italic> (2003) [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Community dwellers 65–75 years. B</td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone <italic>vs.</italic> not: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Residence change: NS <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Community dwellers 75+ <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living alone <italic>vs.</italic> not: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Residence change: NS <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tan <italic>et al.</italic> (2008) [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Singapore</td>
              <td align="left" valign="middle">Patients with major depression <sup>A</sup></td>
              <td align="left" valign="middle">Suicidal thinking</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living arrangement: NS</td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Tsoh <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Nested-Clinical</td>
              <td rowspan="2" align="left" valign="middle">Hong Kong</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide attempt</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living with children: OR = 0.2 (95% CI = 0.03–0.9) <sup>ii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle">In residential facility: OR = 20.0 (95% CI = 2.5–158.1) <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living with children: OR = 0.2 (95% CI = 0.04–0.6) <sup>ii</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Barnow <italic>et al.</italic> (2004) [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Germany</td>
              <td align="left" valign="middle">Community dwellers 70+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide thoughts/attempts</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Living in private home/apartment: 1.2%, senior citizens’ home: 0.2%, nursing home: 0.2%. X2 = 4.3, <italic>p</italic> &lt; 0.05</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Fortin <italic>et al.</italic> (2001) [<xref ref-type="bibr" rid="B29-ijerph-09-00722">29</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Canada</td>
              <td align="left" valign="middle">Nursing home residents 69+ <sup>A</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Months spent in institution: NS</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle">Religion</td>
              <td align="left" valign="middle">Bartels <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Primary care patients with depression <sup>C</sup></td>
              <td align="left" valign="middle">Death ideation/Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Frequency of religious activity: NS</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Yen <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Taiwan</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Religious affiliation <italic>vs.</italic> not: X2 = 4.03, <italic>p</italic> &lt; 0.05 <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Tsoh <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Nested-Clinical</td>
              <td rowspan="2" align="left" valign="middle">Hong Kong</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide attempt</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Ancestor-worshipper: OR = 0.3 (95% CI = 0.1‑0.6) <sup>iv</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle">Religion considered salient: OR = 0.2 (95% CI = 0.1–0.5) <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Religion considered salient: OR = 0.2 (95% CI = 0.1–0.5) <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Turvey <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Attending religious service at least monthly: OR = 0.29 (95% CI = 0.09–0.83)</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Frequency of social contact</td>
              <td align="left" valign="middle">Bartels <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Primary care patients with depression <sup>C</sup></td>
              <td align="left" valign="middle">Death ideation/Suicidal ideation</td>
              <td align="left" valign="middle">Social Network Questionnaire [<xref ref-type="bibr" rid="B43-ijerph-09-00722">43</xref>]</td>
              <td align="left" valign="middle">If any social contacts: Suicide ideation (<italic>vs.</italic> none) OR = 0.86 (95% CI = 0.74–0.99)</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Rowe <italic>et al.</italic> (2006) [<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Homecare patients <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle">Duke Social Support Index [<xref ref-type="bibr" rid="B44-ijerph-09-00722">44</xref>]</td>
              <td align="left" valign="middle">Social interaction: Suicidal ideation: mean = 5.18, no suicidal ideation: mean = 5.89, <italic>p</italic> &lt; 0.05</td>
            </tr>
            <tr>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Turvey <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Population-based</td>
              <td rowspan="2" align="left" valign="middle">USA</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">At least monthly contact with a child: OR = 1.10 (95% CI 0.38–3.58)</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Presence of a relative they see monthly: OR = 0.65 (95% CI 0.33–1.21)</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle">Low social integration</td>
              <td align="left" valign="middle">Dennis <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>]</td>
              <td align="left" valign="middle">Clincal</td>
              <td align="left" valign="middle">UK</td>
              <td align="left" valign="middle">Participants with depression <sup>A</sup></td>
              <td align="left" valign="middle">Self harm behavior (wish to die was reported by most, though not all)</td>
              <td align="left" valign="middle">Social Contact Scale [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>]</td>
              <td align="left" valign="middle">Poorly integrated social network: Self-harm group: 76%, comparisons: 52%, χ<sup>2</sup> = 5.6, <italic>p</italic> &lt; 0.05</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tsoh <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]</td>
              <td align="left" valign="middle">Nested-Clinical</td>
              <td align="left" valign="middle">Hong Kong</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle">Lubben Social Network Scale [<xref ref-type="bibr" rid="B45-ijerph-09-00722">45</xref>]</td>
              <td align="left" valign="middle">Intensity of low social integration OR = 1.1, <italic>p</italic> &lt; 0.05</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle">Lubben Social Network Scale</td>
              <td align="left" valign="middle">Intensity of low social integration OR = 1.1, <italic>p</italic> &lt; 0.05</td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Rowe <italic>et al.</italic> (2006) [<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">USA</td>
              <td align="left" valign="middle">Homecare patients <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle">Duke Social Support Index</td>
              <td align="left" valign="middle">Social network size: B = −0.056, SE: 0.042, Wald = 1.790, df = 1, <italic>p</italic> = 0.18</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Yen <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]</td>
              <td align="left" valign="middle">Population-based</td>
              <td align="left" valign="middle">Taiwan</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicidal ideation</td>
              <td align="left" valign="middle">Neighborhood Quality Index [<xref ref-type="bibr" rid="B46-ijerph-09-00722">46</xref>]</td>
              <td align="left" valign="middle">Community participation: with SI = 14.9%, w/out SI = 34.2% (χ2 = 21.2, <italic>p</italic> &lt; 0.001) <sup>v</sup></td>
            </tr>
            <tr>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Rubenowitz <italic>et al.</italic> (2001) [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Psychological autopsy</td>
              <td rowspan="2" align="left" valign="middle">Sweden</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Club/organization member <italic>vs.</italic> not—by sex: NS <sup>ii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle">Waern <italic>et al.</italic> (2003) [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 65–75 <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Club/organization member <italic>vs.</italic> not: OR = 0.2 (95% CI = 0.1–0.7) <sup>iv</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 75+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Club/organization member <italic>vs.</italic> not: OR = 0.3 (95% CI = 0.1–0.9) <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle">Social support</td>
              <td align="left" valign="middle">Raue <italic>et al.</italic> (2007) [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Clinical</td>
              <td rowspan="2" align="left" valign="middle">USA</td>
              <td rowspan="2" align="left" valign="middle">Homecare patients <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicidal ideation</td>
              <td rowspan="2" align="left" valign="middle">Duke Social Support Index</td>
              <td align="left" valign="middle">Perceived social support: Any DI/SI in past month: OR = 0.87 (95% CI 0.77–0.98).</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Rowe <italic>et al.</italic> (2006) [<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]</td>
              <td align="left" valign="middle">Incident DI/SI over one year: OR = 0.80 (95% CI 0.66–0.98)</td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Duke Social Support Index</td>
              <td align="left" valign="middle">Perceived social support: Suicidal ideation: mean 17.57, no suicidal ideation: mean = 19.27, <italic>p</italic> &lt; 0.01</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Instrumental social support: B = –0.027, SE: 0.065, Wald = 0.169, df = 1, <italic>p</italic> = 0.68</td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td rowspan="2" align="left" valign="middle">Turvey <italic>et al.</italic> (2002) [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Population-based</td>
              <td rowspan="2" align="left" valign="middle">USA</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Relative confidant: OR = 0.54 (95% CI 0.29–0.97)</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Friend confidant: OR = 0.41 (95% CI 0.22–0.74)</td>
            </tr>
            <tr style="border-top: solid thin">
              <td align="left" valign="middle">Loneliness</td>
              <td align="left" valign="middle">Wiktorsson <italic>et al.</italic> (2010) [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Sweden</td>
              <td align="left" valign="middle">Population 70+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle">Single question: Do you feel lonely?</td>
              <td align="left" valign="middle">Feelings of loneliness <italic>vs.</italic> not: OR = 2.8 (95% CI = 1.3–6.1) <sup>ii</sup></td>
            </tr>
            <tr style="border-top: solid thin">
              <td rowspan="2" align="left" valign="middle"> </td>
              <td align="left" valign="middle">Rubenowitz <italic>et al.</italic> (2001) [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Psychological autopsy</td>
              <td rowspan="2" align="left" valign="middle">Sweden</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle">Recent Life Change Questionnaire [<xref ref-type="bibr" rid="B47-ijerph-09-00722">47</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Feelings of loneliness <italic>vs.</italic> not: men: OR = 6.8 (95% CI = 2.6–18.0), women: OR = 8.4 (95% CI = 3.2‑22.3) <sup>iii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle">Waern <italic>et al.</italic> (2003) [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]</td>
            </tr>
            <tr style="border-top: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 65–75 <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle">Recent Life Change Questionnaire</td>
              <td align="left" valign="middle">Feelings of loneliness <italic>vs.</italic> not: OR = 7.6 (95% CI = 2.6–22.3) <sup>iv</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 75+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle">Recent Life Change Questionnaire</td>
              <td align="left" valign="middle">Feelings of loneliness <italic>vs.</italic> not: OR = 5.6 (95% CI = 2.2–14.5) <sup>iv</sup></td>
            </tr>
            <tr>
              <td rowspan="2" align="left" valign="middle">Relationship discord</td>
              <td align="left" valign="middle">Rubenowitz <italic>et al.</italic> (2001) [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]</td>
              <td rowspan="2" align="left" valign="middle">Psychological autopsy</td>
              <td rowspan="2" align="left" valign="middle">Sweden</td>
              <td rowspan="2" align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td rowspan="2" align="left" valign="middle">Suicide</td>
              <td rowspan="2" align="left" valign="middle">Recent Life Change Questionnaire</td>
              <td rowspan="2" align="left" valign="middle">Interpersonal conflict within past 24 months: men: OR = 10.0 (95% CI = 1.7–59.8), women: OR = 9.2 (95% CI = 1.97–44.8) <sup>ii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle">Waern <italic>et al.</italic> (2003) [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]</td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 65–75 <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle">Recent Life Change Questionnaire</td>
              <td align="left" valign="middle">Interpersonal conflict: OR = 13.5 (95% CI = 2.7–60.6) <sup>ii</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers 75+ <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle">Recent Life Change Questionnaire</td>
              <td align="left" valign="middle">Interpersonal conflict: OR = 33.7 (95% CI = 3.1–368.5) <sup>ii</sup></td>
            </tr>
            <tr style="border-top: solid thin; border-bottom: solid thin">
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tsoh <italic>et al.</italic> (2005) [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]</td>
              <td align="left" valign="middle">Nested–Clinical</td>
              <td align="left" valign="middle">Hong Kong</td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide attempt</td>
              <td align="left" valign="middle">Life Event Scale [<xref ref-type="bibr" rid="B48-ijerph-09-00722">48</xref>]</td>
              <td align="left" valign="middle">Family discord: OR = 18.0 (95% CI = 2.3–143.3) <sup>iv</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Community dwellers <sup>B</sup></td>
              <td align="left" valign="middle">Suicide</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Family discord: OR = 41.0 (95% CI = 5.4–313.6) <sup>iv</sup></td>
            </tr>
            <tr>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">Tan <italic>et al.</italic> (2008) [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]</td>
              <td align="left" valign="middle">Clinical</td>
              <td align="left" valign="middle">Singapore</td>
              <td align="left" valign="middle">Patients with major depression <sup>A</sup></td>
              <td align="left" valign="middle">Suicidal thinking</td>
              <td align="left" valign="middle"> </td>
              <td align="left" valign="middle">No relationship difficulties within past month <italic>vs.</italic> relationship difficulties: OR 2.58 (95% CI = 1.01–6.60) <sup>iii</sup></td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot><fn><p>Abbreviations: NS: Not significant. <sup>A</sup> Study size &lt; 100, <sup>B</sup> study size ≥ 100, &lt;1,000, <sup>C</sup> study size ≥ 1,000. <sup>i</sup> Study participants are aged 65 and above unless otherwise specified. <sup>ii</sup> Multivariate regression adjusted for depression and other factors. <sup>iii</sup> Multivariate regression. <sup>iv</sup> Only confirmed in univariate analyses. NS in multivariate analyses. <sup>v</sup> It was furthermore found that “community participation preceding 6-month period was a protective factor from suicidal ideation for those who were male, with religious belief, unemployed, not living alone, with low family income, had physical diseases, and not depressed.” [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>].</p></fn></table-wrap-foot>
      </table-wrap>
      
      <p><italic>Living with family or relative</italic> did not distinguish persons with and without suicidal thinking in the Singapore study by Tan [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]. Living with children was associated with decreased risk for both suicide attempt and death by suicide in the above-cited study by Tsoh [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>], and similar odds ratios were reported for both these outcomes. Barnow reported significant associations for both <italic>living in</italic> <italic>nursing homes and living in senior citizens’ homes</italic> in a German population-based study that identified factors associated death wishes/suicidal thoughts/non-fatal suicidal behavior [<xref ref-type="bibr" rid="B27-ijerph-09-00722">27</xref>]. Institutionalized persons were interviewed in a French-Canadian study by Fortin [<xref ref-type="bibr" rid="B29-ijerph-09-00722">29</xref>], and no association between number of months spent in the institution and suicidal ideation was found. Living in institution did not increase risk of suicide attempt in the Swedish study conducted by Wiktorsson [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. Regarding <italic>change of living arrangement</italic>, Tan could show no association with suicide ideation in the Singapore study, though this question was based on the previous four weeks only [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>]. Residential change over the past two years was not associated with death by suicide in the Swedish study by Rubenowitz [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>], nor when Waern conducted separate analyses for those aged 65–74 years and those aged above 75 [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>].</p>
      <p>Four studies (two from the U.S., one from Hong-Kong and one from Taiwan) examined aspects of <italic>religiosity</italic> [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>,<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>,<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>,<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]. Two of these addressed suicidal ideation. No association could be shown between frequency of religious activity and either death ideation (<italic>i.e.</italic>, wishes for death) or suicide ideation in primary care patients in the U.S.-based study by Bartels [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>]. In a population-based study set in Taiwan, Yen found that having no religious affiliation was more common among those with suicidal ideation than in those without [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]. The acknowledgement of the importance of religious beliefs was associated with reduced risk of both non-fatal and fatal suicidal behavior in the Hong Kong study by Tsoh [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]. Finally, Turvey [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>] reported that persons in the U.S. who died by suicide were less likely to attend religious services at least monthly compared to a community-based comparison group. </p>
      <p>Several U.S. studies (n = 3) examined <italic>frequency of social contact</italic>, with studies by Bartels and Rowe documenting associations between limited social contact and suicidal ideation [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>,<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>] and a study by Turvey showing an association with suicide death [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]. However, when specifically considering contacts with children and relatives, null results were found for death ideation (<italic>i.e.</italic>, passive wishes for death) in the Bartels study [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>] and for suicide in the Turvey study [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]. </p>
      <p>Indices of <italic>low social integration</italic> were examined in five studies. The studies varied in the type of social integration measure that was used. Two studies used composite measures of social integration that include information about quality and quantity of people in subjects’ social networks. For these two studies, significant effects on non-fatal suicidal behavior were observed in the Dennis study from Great Britain [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>] and on both attempted suicide and suicide in Tsoh’s Hong Kong-based study [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]. Rowe examined a single aspect of social integration—the size of the social network in homecare patients in the U.S.—and did not find an effect on suicidal ideation [<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]. Finally, two studies examined another aspect of social integration—<italic>community participation</italic>. Yen noted that older adults in Taiwan who reported suicide ideation were statistically significantly less likely to report that their neighborhood was characterized by community participation [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>]. Decreased suicide risk was observed for Swedish men and women who participated in organizations in the study by Rubenowitz [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]. When stratified analyses were carried out, Waern noted that both younger (65–74) and older (75+) suicide decedents were significantly less involved in such activities than sex- and age-matched comparisons from the general population [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>].</p>
      <p>Two studies (across three publications) explored aspects of <italic>social support</italic>. Raue and Rowe examined both instrumental and perceived social support in a prospective study of older adults receiving home nursing services [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>,<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]. Instrumental support did not differentiate older adults with and without death/suicide ideation [<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>]. However, greater perceived social support was associated with lower risk for both concurrent and one-year incident death/suicide ideation [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>]. Turvey reported that the presence of a relative or friend who was thought of as a confidante was associated with decreased likelihood of suicide [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]. In that study a confidante was defined as someone the older adult felt close to and could talk to about private matters (<italic>i.e.</italic>, a provider of social support). </p>
      <p><italic>Loneliness</italic>—the inner, subjective experience of social disconnectedness—was examined in two Swedish studies (across three publications), documenting increased risk for both non-fatal and fatal suicidal behavior [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>,<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>,<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]. The presence of loneliness was associated with nearly three times greater risk of a suicide attempt in the study by Wiktorsson [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. Rubenowitz reported that loneliness was associated with increased risk of suicide in both men and women [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>]. Further, when Waern [<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>] analyzed data separately for those aged 65–74 years and those aged above 75, loneliness was found to be a stronger predictor among the latter age group.</p>
      <p>An index of discordant connectedness—<italic>relationship discord</italic>—was examined in three publications, documenting associations with non-fatal [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>] and fatal suicidal behavior [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>,<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>,<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]. Analysis of data from the Swedish psychological autopsy study revealed that interpersonal conflict over the prior 24 months was a significant predictor of suicide [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>,<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]. The Tsoh study [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]—described above in the section on social integration—did not find that family discord distinguished between suicide attempts and deaths, but it did distinguish between community controls and both attempts and deaths. In the Singapore-based study by Tan an <italic>absence</italic> of relationship difficulties was associated with greater likelihood of reporting suicidal ideation, even after adjusting for whether the older adults lived alone [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>].</p>
    </sec>
    <sec sec-type="discussion">
      <title>4. Discussion</title>
      <p>This systematic review yielded 16 publications on social factors and suicidal behaviors in persons aged 65 and above. These studies were based on data from 14 studies set in three continents (U.S. and Canada n = 6, Europe (Germany, Sweden, and United Kingdom) n = 4, and Asia (Hong Kong, Japan, Singapore, Taiwan) n = 4). Before discussing the results, some issues related to methods need to be noted. Inclusion age was 65 years and older and only studies that employed similar age comparison groups were included. The rationale for this was that rates of suicidal behavior and social factors associated with such behavior vary widely by geographic region. We wanted to identify studies that provided odds ratios for this specific age group. We included marital status and living arrangements in our review because these factors can help to define the target population. Participation in religious activities was also included, as religious centers may in some settings provide important occasions for social interaction. </p>
      <p>Our review has a number of limitations. We included a broadly defined range of suicidal behaviors (death wishes, suicide ideation, non-fatal and fatal suicidal behavior). It cannot be assumed that these phenomena share the same risk factors. Further, a meta-analysis was not feasible given the limited number of publications, and the broad spectrum of recruitment procedures, variables of interest, and instruments employed. A final caveat is that, with the exception of the study by Rubenowitz and colleagues [<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>], sex-specific data for older adults were lacking. This is particularly problematic considering the vast sex differential in suicide rates observed among older adults in most industrialized countries for which suicide data are available [<xref ref-type="bibr" rid="B20-ijerph-09-00722">20</xref>]. Although there is evidence of gendered norms of suicidal behavior in countries with large sex differentials (for example, in the United States, non-fatal suicidal behavior is considered feminine while suicide is more acceptable in men than in women [<xref ref-type="bibr" rid="B49-ijerph-09-00722">49</xref>]), more research is needed to elucidate the details of cultural scripts of gender and suicidal behavior within and between countries. It is probable that gendered beliefs and experiences play a role in the association between social factors and suicide [<xref ref-type="bibr" rid="B20-ijerph-09-00722">20</xref>,<xref ref-type="bibr" rid="B50-ijerph-09-00722">50</xref>], just as there are gender-related differences in the link between physical illness and suicide [<xref ref-type="bibr" rid="B51-ijerph-09-00722">51</xref>].</p>
      <p>The majority of the social factors examined in this review can be conceptualized as indices of social connectedness—the degree of positive connectedness to family, friends, and social groups. However, the most often-studied factors—marital status, living arrangements, and frequency of social contact—yielded the most inconsistent results across studies (see <xref ref-type="table" rid="ijerph-09-00722-t002">Table 2</xref>). Heterogeneity across studies may be attributed to the fact that such factors are poor indicators of the subjectively experienced degree of social connectedness. This apparent heterogeneity is systematically moderated by macro- or national-level influences, for example, cultural scripts of gender and suicidal behavior [<xref ref-type="bibr" rid="B49-ijerph-09-00722">49</xref>] that we did not examine. </p>
      <table-wrap id="ijerph-09-00722-t002" position="anchor">
        <object-id pub-id-type="pii">ijerph-09-00722-t002_Table 2</object-id>
        <label>Table 2</label>
        <caption>
  <p>Box score summary of review findings.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th rowspan="2" align="left" valign="middle">Variable</th>
              <th rowspan="2" align="center" valign="middle">Number of studies</th>
              <th colspan="3" align="center" valign="middle">Some evidence of association with outcome</th>
            </tr>
            <tr style="border-top: solid thin">
              <th valign="middle">Yes</th>
              <th valign="middle">Mixed</th>
              <th valign="middle">No</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="middle">Marital status</td>
              <td align="center" valign="middle">11</td>
              <td align="center" valign="middle">4</td>
              <td align="center" valign="middle"> </td>
              <td align="center" valign="middle">7</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Living arrangement</td>
              <td align="center" valign="middle">11</td>
              <td align="center" valign="middle">3</td>
              <td align="center" valign="middle">1</td>
              <td align="center" valign="middle">7</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Religion</td>
              <td align="center" valign="middle">4</td>
              <td align="center" valign="middle">3</td>
              <td align="center" valign="middle"> </td>
              <td align="center" valign="middle">1</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Frequency of social contact</td>
              <td align="center" valign="middle">3</td>
              <td align="center" valign="middle">1</td>
              <td align="center" valign="middle">2</td>
              <td align="center" valign="middle"> </td>
            </tr>
            <tr>
              <td align="left" valign="middle">Low social integration</td>
              <td align="center" valign="middle">5</td>
              <td align="center" valign="middle">4</td>
              <td align="center" valign="middle"> </td>
              <td align="center" valign="middle">1</td>
            </tr>
            <tr>
              <td align="left" valign="middle">Social support</td>
              <td align="center" valign="middle">2</td>
              <td align="center" valign="middle">1</td>
              <td align="center" valign="middle">1</td>
              <td align="center" valign="middle"> </td>
            </tr>
            <tr>
              <td align="left" valign="middle">Loneliness</td>
              <td align="center" valign="middle">2</td>
              <td align="center" valign="middle">2</td>
              <td align="center" valign="middle"> </td>
              <td align="center" valign="middle"> </td>
            </tr>
            <tr>
              <td align="left" valign="middle">Relationship discord</td>
              <td align="center" valign="middle">3</td>
              <td align="center" valign="middle">3 <sup>A</sup></td>
              <td align="center" valign="middle"> </td>
              <td align="center" valign="middle"> </td>
            </tr>
          </tbody>
  </table>
        <table-wrap-foot><fn><p><sup>A</sup> One study found that <italic>absence</italic> of relationship discord was associated with suicidal ideation [<xref ref-type="bibr" rid="B33-ijerph-09-00722">33</xref>].</p></fn></table-wrap-foot>
      </table-wrap>
      
      <p>Most of the studies that examined marital status did not show an association with suicidal behavior. While being married is often associated with better health outcomes, especially for men, marital status <italic>per se</italic> tells us nothing about the quality of the relationship. Even marriages that have lasted for decades can come under strain when age-related changes affect one or both of the partners. Loss of mental and physical health and functional ability are examples of factors that can vastly change circumstances for a married couple. Bereavement is common in later life, and there is evidence that risk of suicide is particularly heightened in older men who have lost a spouse. In a population-based register study of the entire Danish population aged fifty year and older, Erlangsen and colleagues showed that men aged 80 years and above who had lost their partner during the past year had a 15-fold increase in suicide risk compared to married middle-aged men [<xref ref-type="bibr" rid="B52-ijerph-09-00722">52</xref>]. </p>
      <p>Only two of the eleven studies that examined living arrangement reported an association between living alone and the outcomes of interest, one from Japan [<xref ref-type="bibr" rid="B37-ijerph-09-00722">37</xref>] and another from Sweden [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>]. The variable living alone simply designates that the person is the sole resident in the dwelling; it does not capture the surrounding social circumstances. The living alone variable could be confounded by other factors. For example, those who live with their children would belong to the group who do not live alone, and living with children was associated with a decreased risk for both non-fatal and fatal suicidal behavior in the Hong Kong study [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>]. Further, a person with a limited social network might be more likely to require institutional care, whereas one with a large social network might receive support that enables continued living at home. </p>
      <p>Rather consistent results were found in this review for religious participation, with four analyses across three studies from Taiwan [<xref ref-type="bibr" rid="B34-ijerph-09-00722">34</xref>], Hong Kong [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>], and the U.S. [<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>] documenting inverse associations with ideation, non-fatal and fatal suicidal behavior. Two U.S.-based studies focusing on persons aged 50 and above found that those who died by suicide less frequently took part in religious activities, compared to those who died of natural causes [<xref ref-type="bibr" rid="B53-ijerph-09-00722">53</xref>,<xref ref-type="bibr" rid="B54-ijerph-09-00722">54</xref>]. One of these [<xref ref-type="bibr" rid="B54-ijerph-09-00722">54</xref>] demonstrated that those who did participate in religious activities had a less active role in the congregation compared to their counterparts. Another study that focused on medically ill older persons found that church attendance and private religious activities did not predict shorter time to remission of depression, but religious beliefs (intrinsic religiosity) did [<xref ref-type="bibr" rid="B55-ijerph-09-00722">55</xref>]. Religious activities often provide an important channel for social interaction, even for those who cannot physically attend services. A functionally impaired older adult may find a sense of connectedness to the religious community, for example through radio or other media, or through home visits by clergy or congregation members. This may be particular important for older men, given men’s less developed connectedness with family, relative to older women [<xref ref-type="bibr" rid="B20-ijerph-09-00722">20</xref>].</p>
      <p>Three of the five analyses of frequency of social contact (across 3 studies, all from the U.S. [<xref ref-type="bibr" rid="B28-ijerph-09-00722">28</xref>,<xref ref-type="bibr" rid="B32-ijerph-09-00722">32</xref>,<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]) yielded significant associations between low contact and both suicide ideation and suicide. An additional case-control New Zealand study with a lower inclusion age (55+) [<xref ref-type="bibr" rid="B56-ijerph-09-00722">56</xref>] also documented an association between low social contact and suicide, but a Canadian study (60+) that examined contacts during the last six months showed no difference between suicide decedents and control subjects [<xref ref-type="bibr" rid="B57-ijerph-09-00722">57</xref>]. No associations were observed in the studies reviewed when social contacts included only family, tentatively suggesting that contacts with friends may be particularly protective. Most studies documenting significant effects used “less than monthly contact” as the indicator of limited social contact. A more “severe” indicator of infrequent social contact (<italic>i.e.</italic>, no contact in the previous year) was used in a British study [<xref ref-type="bibr" rid="B58-ijerph-09-00722">58</xref>] that compared older adults (60+) who died by suicide to those who died in hospital by natural causes. While the proportion with less than daily contact with friends/relatives in the year before death was numerically smaller in the suicide group, no difference could be shown. Of course the risk for premature mortality conferred by infrequent social contact is not specific to suicide [<xref ref-type="bibr" rid="B59-ijerph-09-00722">59</xref>], though the strength of the association, as well as underlying mechanisms, may differ as a function of type of health outcomes (e.g., cancer mortality, as compared to suicide mortality). </p>
      <p>Three analyses across two independent studies, one from Great Britain [<xref ref-type="bibr" rid="B36-ijerph-09-00722">36</xref>] and another from Hong Kong [<xref ref-type="bibr" rid="B38-ijerph-09-00722">38</xref>], established a consistent association between low social integration and fatal and non-fatal suicidal behavior. Further, the results of these studies suggest that the effect is not due solely to depression. Though investigated in fewer studies, consistent results were also found for subjective measures of social connectedness—perceived social support (two U.S. studies [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>,<xref ref-type="bibr" rid="B41-ijerph-09-00722">41</xref>]) and loneliness (two Swedish studies [<xref ref-type="bibr" rid="B39-ijerph-09-00722">39</xref>,<xref ref-type="bibr" rid="B40-ijerph-09-00722">40</xref>,<xref ref-type="bibr" rid="B42-ijerph-09-00722">42</xref>]). Low instrumental support, in a single U.S. study [<xref ref-type="bibr" rid="B31-ijerph-09-00722">31</xref>], was not associated with suicide. Reasons for this were not examined. Other research indicates stronger benefits for giving versus receiving support [<xref ref-type="bibr" rid="B60-ijerph-09-00722">60</xref>]. Further, there are findings indicating associations with perceiving oneself as a burden and suicide risk in later life [<xref ref-type="bibr" rid="B16-ijerph-09-00722">16</xref>]. Taken together, these findings suggest that instrumental support should be measured separately from other types of social support, such as emotional support and companionship, because some specific aspects of social support may mitigate risk of suicidal behavior. </p>
      <p>Qualitative studies can provide insights on individuals’ perceived social connectedness- or lack thereof. A recent Norwegian psychological autopsy study used a qualitative approach to explore relationships between the informants and the older adult (65+) who died by suicide. Findings showed that the relationships were often difficult and distant [<xref ref-type="bibr" rid="B61-ijerph-09-00722">61</xref>]. In a qualitative study set in Britain, participants (aged 65 and above) described feeling disconnected to their surroundings prior to their suicidal act. For some, successful coping after the act meant becoming more connected and more visible to others [<xref ref-type="bibr" rid="B62-ijerph-09-00722">62</xref>]. </p>
    </sec>
    <sec>
      <title>5. Future Research</title>
      <p>The need for future research is clearly identified by the fact that our broad inclusion criteria yielded a limited number of studies to be reviewed. As populations age, it will be increasingly important to elucidate risk estimates for social factors associated with suicidal behaviors also in oldest old populations. Further, studies need to be carried out in different settings throughout the world, in order increase understanding of how societal and cultural conditions may shape the influence of social factors on suicide. The relevance of Durkheim’s theories remains to be elucidated with regard to suicidal behavior in older persons. </p>
      <p>Future research may include assessment of subjective accounts of social connectedness (<italic>i.e.</italic>, perceived social support, loneliness), as well as social integration and participation (<italic>i.e.</italic>, complex social integration measures and participation in clubs). Qualitative studies with a focus on experiences of social connectedness/thwarted belongingness in older persons with non-fatal suicidal behavior could provide important knowledge that quantitative studies cannot provide. In the studies using the psychological autopsy approach, this will require asking close informants to provide data pertaining to the decedent’s subjective experience of loneliness. Much has been learned over the past decade about the capacity of informants to provide “accurate” data about the internal state of another person [<xref ref-type="bibr" rid="B63-ijerph-09-00722">63</xref>,<xref ref-type="bibr" rid="B64-ijerph-09-00722">64</xref>], including in older adults [<xref ref-type="bibr" rid="B65-ijerph-09-00722">65</xref>,<xref ref-type="bibr" rid="B66-ijerph-09-00722">66</xref>]. For example, it has been shown that informants are likely to over-estimate self-consciousness and to underestimate the extent to which someone experiences positive emotions. Some of these discrepancies can be ascribed in part to the person’s level of cognitive function or medical burden [<xref ref-type="bibr" rid="B66-ijerph-09-00722">66</xref>]. These and similar findings could inform the next generation of psychological autopsy research. </p>
      <p>To date, relatively few studies of elderly and suicidal behavior have included questions regarding religiosity, as shown in this review. The multidimensionality of religion makes the phenomenon difficult to study. However, assessment of the individual’s religiosity should be considered in future studies. The impact that culture and gender has on religion and its impact on suicidal behavior needs to be taken into consideration in future research [<xref ref-type="bibr" rid="B67-ijerph-09-00722">67</xref>]. </p>
      <p>A life course perspective, one that considers longstanding personality traits known to influence suicide [<xref ref-type="bibr" rid="B68-ijerph-09-00722">68</xref>,<xref ref-type="bibr" rid="B69-ijerph-09-00722">69</xref>] as well as age related changes in social roles and networks, can provide further understanding. Some suicidal older persons may have had a rich social network that became restricted in the context of aging. For others, lack of social connectedness may have been a more enduring experience, perhaps related to personality [<xref ref-type="bibr" rid="B70-ijerph-09-00722">70</xref>]. Results from a qualitative study focusing on U.S. older women showed that those who were suicidal experienced loneliness in childhood, and no confidants during adolescence and adulthood [<xref ref-type="bibr" rid="B71-ijerph-09-00722">71</xref>]. </p>
      <p>A neuropsychological perspective may also provide further insight into suicidal behavior among older adults. A recent U.S. study that focused on depressed <bold>s</bold>uicide attempters aged 60 and above found that social cognition deficits differentiated individuals who had engaged in suicidal behavior from mentally healthy controls [<xref ref-type="bibr" rid="B72-ijerph-09-00722">72</xref>]. Specifically, individuals in the former group demonstrated significantly more errors on the Reading the Mind in the Eyes test, which measures emotion recognition capabilities by having participants make subtle discriminations between photographs of facial expressions. As indicated by the authors, difficulties with emotion recognition could impair social problem solving, lead to conflict in social interactions, and result in lower feelings of social connectedness and belonging.</p>
      <p>Theoretical perspectives are also relevant and may generate directions for future research. The Interpersonal Theory of Suicide [<xref ref-type="bibr" rid="B16-ijerph-09-00722">16</xref>] proposes that individuals have intrinsic needs to belong to meaningful relationships and groups. If this need is thwarted, and the individual has a perception of being a burden on others, this will result in a desire for suicide. Recent U.S. research examining the theory with older adults indicates that perceived burdensomeness is associated with more severe suicidal ideation above and beyond the contribution of belongingness [<xref ref-type="bibr" rid="B73-ijerph-09-00722">73</xref>,<xref ref-type="bibr" rid="B74-ijerph-09-00722">74</xref>]. Thus, interventions that alleviate feelings of thwarted belongingness and burdensomeness are relevant to late-life suicide prevention in the U.S. Finally, progress in understanding late life suicidal behavior requires attention to its cultural meanings [<xref ref-type="bibr" rid="B75-ijerph-09-00722">75</xref>]. The cultural script theory of suicidal behavior [<xref ref-type="bibr" rid="B75-ijerph-09-00722">75</xref>] points to ways to understand the gender gap in older adult suicidal behavior found in many industrialized countries via a focus on gendered meanings of suicidality as well as on the gendered experiences of social connectedness in these countries [<xref ref-type="bibr" rid="B20-ijerph-09-00722">20</xref>], with implications for prevention. </p>
      <p>A number of carefully designed, multidisciplinary, prospective studies of older adult cohorts implemented in the 1970’s continue to yield insights into suicide risk [<xref ref-type="bibr" rid="B76-ijerph-09-00722">76</xref>,<xref ref-type="bibr" rid="B77-ijerph-09-00722">77</xref>,<xref ref-type="bibr" rid="B78-ijerph-09-00722">78</xref>]. A new generation of large-scale prospective studies can broaden our knowledge of the determinants and course of social connectedness and the development of suicidal behavior in older individuals over time, which can help to inform appropriate interventions.</p>
    </sec>
    <sec>
      <title>6. Implications for Suicide Prevention</title>
      <p>Controversy abounds concerning the labels used to designate suicide prevention research. Several typologies have been proposed [<xref ref-type="bibr" rid="B79-ijerph-09-00722">79</xref>,<xref ref-type="bibr" rid="B80-ijerph-09-00722">80</xref>,<xref ref-type="bibr" rid="B81-ijerph-09-00722">81</xref>,<xref ref-type="bibr" rid="B82-ijerph-09-00722">82</xref>]. Distinctions have been drawn between high-risk approaches and population-based approaches [<xref ref-type="bibr" rid="B79-ijerph-09-00722">79</xref>,<xref ref-type="bibr" rid="B80-ijerph-09-00722">80</xref>] and between universal, targeted, selective, and indicated approaches [<xref ref-type="bibr" rid="B81-ijerph-09-00722">81</xref>,<xref ref-type="bibr" rid="B82-ijerph-09-00722">82</xref>]. For our purposes, a key issue is whether or not programs target populations on the basis of a clinical risk factor (depression, suicide ideation, non-fatal suicidal behavior). Following Kaplan [<xref ref-type="bibr" rid="B79-ijerph-09-00722">79</xref>], these two approaches are labeled secondary prevention and primary prevention. </p>
      <p>Guided by a medical model of health, secondary prevention targets the clinical conditions and diseases known to confer suicide risk (e.g., major depression). Ideally, this would involve determining whether an evidence-based treatment offered to patients with a clinical condition (such as major depression with suicide ideation and feelings of loneliness) leads to fewer suicides over a follow-up period than a control treatment. Research indicates that indices of social connectedness are modifiable among older adults using social interventions, including group psychotherapy [<xref ref-type="bibr" rid="B83-ijerph-09-00722">83</xref>], art/recreational therapy [<xref ref-type="bibr" rid="B84-ijerph-09-00722">84</xref>,<xref ref-type="bibr" rid="B85-ijerph-09-00722">85</xref>,<xref ref-type="bibr" rid="B86-ijerph-09-00722">86</xref>,<xref ref-type="bibr" rid="B87-ijerph-09-00722">87</xref>], and peer support [<xref ref-type="bibr" rid="B88-ijerph-09-00722">88</xref>]. Among middle-aged adults, cognitive behavior therapy has also been shown to be effective [<xref ref-type="bibr" rid="B89-ijerph-09-00722">89</xref>]. Interpersonal psychotherapy has been shown to reduce suicide ideation among older adults [<xref ref-type="bibr" rid="B90-ijerph-09-00722">90</xref>]. Further, primary care providers may wish to consider the implications of their practice patterns for their patients’ experiences of care and connectedness. Office space, the behavior of office staff, and provider interviewing techniques may all affect patients’ experiences of care and being cared for.</p>
      <p>Major problems in suicide prevention are the paucity of specialized mental health services and the reluctance of many at-risk people, especially men, to avail themselves of treatment due to stigma [<xref ref-type="bibr" rid="B91-ijerph-09-00722">91</xref>] and social norms [<xref ref-type="bibr" rid="B92-ijerph-09-00722">92</xref>]. Primary prevention may be particularly useful in mitigating risk among individuals, who, for whatever reason, do not access mental health services. Guided by a behavioral model of health, the main targets of primary prevention programs are typically health behaviors and health decision-making [<xref ref-type="bibr" rid="B79-ijerph-09-00722">79</xref>]: alcohol, tobacco, drug use, maintenance of a healthful diet, exercise, and safety (with regard to sexual behavior, food, medication, transportation, firearms). Primary prevention programs of greatest demonstrable relevance to suicide in communities where firearms and medications are dominant suicide methods include legislation restricting access to unsafe firearms as well as mandates concerning the manufacturing, packaging, and distribution of medications [<xref ref-type="bibr" rid="B93-ijerph-09-00722">93</xref>,<xref ref-type="bibr" rid="B94-ijerph-09-00722">94</xref>]. Public health messaging interventions designed to modify attitudes about aging, the receipt of mental health services, and the acceptability of suicide might also influence suicide rates. Primary prevention programs designed to enhance positive social connections between neighbors as well as a sense of community might also decrease suicide risk. These programs may prove to be particularly effective because they do not require people to make an active choice (to see a doctor, take a medication), and typically do not threaten to undermine individual autonomy [<xref ref-type="bibr" rid="B95-ijerph-09-00722">95</xref>]. Further, these programs can reduce a host of negative outcomes beyond suicide. Such programs would involve collaborations among social scientists, physicians, community leaders, including religious leaders, and experts in environmental planning and design. </p>
    </sec>
    <sec sec-type="conclusions">
      <title>7. Conclusions</title>
      <p>Findings of this review of the literature on social factors in older adult suicidal behavior suggest that limited social connectedness is associated with suicidal ideation, non-fatal suicidal behavior, and suicide in later life, at least in industrialized countries. Primary prevention programs designed to enhance social connections as well as a sense of community could potentially decrease suicide risk. Such programs would involve collaborations among social scientists, physicians, community leaders including religious leaders, and experts in environmental planning and design.</p>
    </sec>
  </body>
  <back>
    <ack>
    <title>Acknowledgments</title>
      <p>This review involved a collaboration within the International Association for Suicide Prevention Interest Group on Suicide in Older Adults. Contact persons for the Interest Group are Annette Erlangsen (aerlangs@jhsph.edu) and Sylvie Lapierre (Sylvie.Lapierre@uqtr.ca). The study was made possible by Grant No. K2009-62X-21079-01-3 from the Swedish Research Council, Grant No. 2008-1229 from the Council for Working Life and Social Research (FAS), and Grant No. T32MH20061 from the National Institute of Mental Health.</p>
    </ack>
    <notes>
    <title>Conflict of Interest</title>
      <p>The authors declare no conflict of interest.</p>
    </notes>
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