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Int. J. Environ. Res. Public Health 2011, 8(3), 899-912; doi:10.3390/ijerph8030899

Clinical, Radiological, and Pathological Investigation of Asbestosis

Asbestos Research Center, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Minamiku Okayama City, 702-8055, Japan
Department of Radiology, Okayama University School of Medicine, 2-5-1,Shikata-cho, Kitaku, Okayama City, 702-8558, Japan
Department of Radiology, Dokkyo Medical University, 880, Kitakobayashi, Mibumati, Shimotuga-gun, Tochigi City, 321-0293, Japan
Department of Radiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki City, 852-8501, Japan
Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima City, 734-0037, Japan
Author to whom correspondence should be addressed.
Received: 24 February 2011 / Revised: 18 March 2011 / Accepted: 20 March 2011 / Published: 22 March 2011
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By the radiological examination, differential diagnosis of asbestosis from chronic interstitial pneumonia such as IPF/UIP is difficult. The pathological features of asbestosis show the peribronchiolar fibrosis which suggest that asbestos fibers cause the inflammation of bronchioli. Therefore, the criteria for pathological diagnosis of asbestosis in 2010, contain the finding of peribronchiolar fibrosis again. Chest CT scanning including HRCT for total of 38 cases clinically diagnosed asbestosis were reviewed by 3 radiologists and one pulmonologist. On the other hand, the histology of lung tissues obtained by surgery or autopsy were examined by 4 pulmonological pathologists. Furthermore, the content of asbestos bodies in the lung was counted by phase-contrast microscopy. Thirteen cases were definitely diagnosed of asbestosis in the image including HRCT and 17 cases were diagnosed by the histopathological examination showing lung fibrosis with peribronchiolar fibrosis. Only 10 cases were indicated asbestosis by both the radiological and histopathological examinations. The mean value of asbestos bodies for these cases, was 2,133,255 per gram of dry lung tissue.
Keywords: asbestosis; peribronchiolar fibrosis; IPF/UIF; asbestos body asbestosis; peribronchiolar fibrosis; IPF/UIF; asbestos body
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kishimoto, T.; Kato, K.; Arakawa, H.; Ashizawa, K.; Inai, K.; Takeshima, Y. Clinical, Radiological, and Pathological Investigation of Asbestosis. Int. J. Environ. Res. Public Health 2011, 8, 899-912.

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