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Int. J. Environ. Res. Public Health 2010, 7(7), 2988-3005; doi:10.3390/ijerph7072988
Article

Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

1,2
, 3,4
, 2
, 5
 and 1,6,7,*
1 Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, 35294, USA 2 Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA 3 Department of Psychology, Old Dominion University, 250 Mills Godwin Building, Norfolk, VA 23529, USA 4 Department of Mathematics and Statistics, Old Dominion University, 250 Mills Godwin Building, Norfolk, VA 23529, USA 5 Institute of Environmental Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA 6 Department of Nutrition Sciences, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA 7 Clinical Nutrition Research Center, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
* Author to whom correspondence should be addressed.
Received: 16 June 2010 / Revised: 16 July 2010 / Accepted: 19 July 2010 / Published: 23 July 2010
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Abstract

Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999–2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p’ DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p’ DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.
Keywords: Obesity; endocrine disruptors; waist circumference; persistent organic pollutants; public health Obesity; endocrine disruptors; waist circumference; persistent organic pollutants; public health
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Elobeid, M.A.; Padilla, M.A.; Brock, D.W.; Ruden, D.M.; Allison, D.B. Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data. Int. J. Environ. Res. Public Health 2010, 7, 2988-3005.

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