Int. J. Environ. Res. Public Health 2010, 7(12), 4127-4138; doi:10.3390/ijerph7124127
Article

A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real-Time VOC and Holter Monitors

Received: 18 October 2010; Accepted: 18 November 2010 / Published: 30 November 2010
(This article belongs to the Special Issue Indoor Air Pollution and Human Health)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effrects to relate their values to the personal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions. The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating a suppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system.
Keywords: real-time monitoring; VOCs; heart rate variability (HRV); Holter monitor
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MDPI and ACS Style

Mizukoshi, A.; Kumagai, K.; Yamamoto, N.; Noguchi, M.; Yoshiuchi, K.; Kumano, H.; Yanagisawa, Y. A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real-Time VOC and Holter Monitors. Int. J. Environ. Res. Public Health 2010, 7, 4127-4138.

AMA Style

Mizukoshi A, Kumagai K, Yamamoto N, Noguchi M, Yoshiuchi K, Kumano H, Yanagisawa Y. A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real-Time VOC and Holter Monitors. International Journal of Environmental Research and Public Health. 2010; 7(12):4127-4138.

Chicago/Turabian Style

Mizukoshi, Atsushi; Kumagai, Kazukiyo; Yamamoto, Naomichi; Noguchi, Miyuki; Yoshiuchi, Kazuhiro; Kumano, Hiroaki; Yanagisawa, Yukio. 2010. "A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real-Time VOC and Holter Monitors." Int. J. Environ. Res. Public Health 7, no. 12: 4127-4138.

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