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Int. J. Environ. Res. Public Health 2009, 6(12), 3179-3189; doi:10.3390/ijerph6123179
Article

An Exploratory Study of Diabetes in a First Nation Community with Respect to Serum Concentrations of p,p’-DDE and PCBs and Fish Consumption

1,* , 2
 and
1
Received: 4 November 2009 / Accepted: 2 December 2009 / Published: 11 December 2009
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Abstract

This study examined the association between self-reported diabetes, fish consumption and serum levels of organochlorines in a First Nation community. One quarter of the 101 participants reported diabetes. Serum PCBs, but not p,p’-DDE, were positively correlated to consumption frequency of total fish, walleye and pike, but not trout. Reported diabetes was positively associated to p,p’-DDE and some PCB congeners. Odds Ratios (OR) for reported diabetes for those in the upper 75th percentile for serum p,p’-DDE compared to the others were 3.5 (95% CI 1–13.8) and 6.1 (95% CI 1.4–27.3) (weight wet and lipid-standardized values, respectively) and for total sum of PCBs: 4.91 (95% CI 1.4–19.0) and 5.51 (95% CI 1.3–24.1). For participants who were in the upper 50th percentile for trout and white fish intake, reported diabetes was respectively 6 and 4 times lower compared to the others. These findings support the hypothesis that environmental exposure to elevated p,p’-DDE and PCBs is associated with increased risk of diabetes. Consumption of trout and white fish may be beneficial to reduce risk.
Keywords: First Nation; diabetes; fish; organochlorines; DDE; PCB First Nation; diabetes; fish; organochlorines; DDE; PCB
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Philibert, A.; Schwartz, H.; Mergler, D. An Exploratory Study of Diabetes in a First Nation Community with Respect to Serum Concentrations of p,p’-DDE and PCBs and Fish Consumption. Int. J. Environ. Res. Public Health 2009, 6, 3179-3189.

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