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Int. J. Environ. Res. Public Health 2009, 6(1), 329-348; doi:10.3390/ijerph6010347

New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms

Children’s Hospital and Harvard Medical School, Karp Family Laboratories, 300 Longwood Avenue, Boston, MA 02115, USA
Received: 6 November 2008 / Accepted: 10 January 2009 / Published: 20 January 2009
(This article belongs to the Special Issue Public Health: Feature Papers)

Abstract

A small international group has recently challenged fundamental concepts in breast cancer. As a guiding principle in therapy, it has long been assumed that breast cancer growth is continuous. However, this group suggests tumor growth commonly includes extended periods of quasi-stable dormancy. Furthermore, surgery to remove the primary tumor often awakens distant dormant micrometastases. Accordingly, over half of all relapses in breast cancer are accelerated in this manner. This paper describes how a numerical algorithm was used to come to these conclusions. Based on these findings, a dormancy preservation therapy is proposed.
Keywords: Breast cancer; quasi-stable dormancy; surgery-induced angiogenesis; dormancy preservation therapy Breast cancer; quasi-stable dormancy; surgery-induced angiogenesis; dormancy preservation therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Retsky, M. New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms. Int. J. Environ. Res. Public Health 2009, 6, 329-348.

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