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Int. J. Environ. Res. Public Health 2018, 15(3), 414; https://doi.org/10.3390/ijerph15030414

Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

1
Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
2
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
3
School of Chemistry, Shoolini University, Solan 173212, India
4
Department of Chemistry, College of Science, Bld.#5, King Saud University, Riyadh 11451, Saudi Arabia
5
School of Pharmaceutical Sciences, Shoolini University, Solan 173212, India
6
School of Applied Science and Biotechnology, Shoolini University, Solan 173212, India
7
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, India
8
School of Public Health, 3rd Floor, SRM Medical College and Research, Centre, Kattankulathur 603211, India
*
Authors to whom correspondence should be addressed.
Received: 29 December 2017 / Revised: 19 February 2018 / Accepted: 23 February 2018 / Published: 27 February 2018
(This article belongs to the Section Environmental Science and Engineering)
View Full-Text   |   Download PDF [2959 KB, uploaded 27 February 2018]   |  

Abstract

Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature. View Full-Text
Keywords: sodium dodecyl sulphate; nanocomposite; drug delivery; ondansetron sodium dodecyl sulphate; nanocomposite; drug delivery; ondansetron
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Sharma, G.; Naushad, M.; Thakur, B.; Kumar, A.; Negi, P.; Saini, R.; Chahal, A.; Kumar, A.; Stadler, F.J.; Aqil, U. Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron. Int. J. Environ. Res. Public Health 2018, 15, 414.

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