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Int. J. Environ. Res. Public Health 2018, 15(1), 161; https://doi.org/10.3390/ijerph15010161

Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa

1
HIV/Aids, STI and TB Unit, Human Sciences Research Council, Private Bag X41, Pretoria 0001, South Africa
2
Department of Work & Social Psychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
3
Department of Research and Innovation, University of Limpopo, Sovenga 0727, South Africa
4
Miller School of Medicine, University of Miami, 1400 NW 10th Ave, Miami, FL 33136, USA
*
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 12 January 2018 / Accepted: 19 January 2018 / Published: 20 January 2018
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Abstract

The possibility for all babies to be born and remain HIV-negative for the first year of life is achievable in South Africa. HIV-positive mothers’ adherence to their antiretroviral medication is one of the crucial factors to achieve this target. Cross-sectional data were collected at 12 community health centres, over 12 months (2014–2015), from 673 HIV-positive women, less than 6 months pregnant, attending antenatal care, and on Option B treatment. Adherence measures included the Adults AIDS Clinical Trials Group (AACTG) four-day measure, as well as the Visual Analog Scale (VAS) seven-day measure. Bivariate analyses and multivariate logistic regressions are presented. 78.8% of respondents were adherent on AACTG, while 68.8% reported VAS adherence. Bivariate analyses for increased adherence show significant associations with older age, less/no alcohol usage, disclosure of HIV status, higher HIV knowledge, no desire to avoid ARV side effects, low stigma, and low depression. AACTG showed a negative association with intimate partner violence. Multivariable logistic regression on AACTG and VAS adherence rates resulted in unique contributions to increased adherence of older age, less/no alcohol usage, higher HIV knowledge, lack of depression, and non-disclosure. Programs targeting closer side effect monitoring, HIV disclosure, pre-natal depression, alcohol intake, and HIV knowledge need consideration. View Full-Text
Keywords: HIV/AIDS; pregnant; ARVs; adherence; Option B HIV/AIDS; pregnant; ARVs; adherence; Option B
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ramlagan, S.; Peltzer, K.; Ruiter, R.A.C.; Barylski, N.A.; Weiss, S.M.; Sifunda, S. Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa. Int. J. Environ. Res. Public Health 2018, 15, 161.

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