Next Article in Journal
Using Health Impact Assessment as an Interdisciplinary Teaching Tool
Previous Article in Journal
Do Inequalities in Neighborhood Walkability Drive Disparities in Older Adults’ Outdoor Walking?
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(7), 743; doi:10.3390/ijerph14070743

In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention

1
Department of Substitutive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia
2
Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia
3
Department of Physiology, College of Medicine, University of Dammam, Dammam 32214, Saudi Arabia
4
Department of Biomedical Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia
5
Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh 11692, Saudi Arabia
6
Department of Oral Rehabilitation, Dental College of Georgia, Augusta University, Augusta 30912, GA, USA
Current address: Oral Pathology and Oral Medicine, Faculty of Dentistry, University of Toronto, 124 Edward St. Room 314, Toronto, ON M5G 1G6, Canada.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 11 June 2017 / Revised: 29 June 2017 / Accepted: 3 July 2017 / Published: 8 July 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [696 KB, uploaded 8 July 2017]   |  

Abstract

Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans. Eighty acrylic resin specimens were fabricated and divided into eight groups (n = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on Candida albicans: the slide count and the serial dilution test. A multivariate analysis of variance (MANOVA) and the post-hoc Tukey’s Honestly Significant Difference (HSD) test were performed to compare the difference of means between the observations taken at various intervals with baseline. The p value was statistically significant at ≤0.05. According to the slide count and the serial dilution test, the mean number of adhered Candida albicans in the control group was 5436.9 ± 266 and 4691.4 ± 176.8; however, this number dramatically decreased to 0 ± 0 and 32.4 ± 1.7 in group 8 (concentration 5%). These results suggest that the incorporation of thymoquinone into the acrylic resin denture base material might be effective in preventing Candida albicans adhesion. View Full-Text
Keywords: Candida albicans; black seeds; denture base; denture stomatitis; thymoquinone Candida albicans; black seeds; denture base; denture stomatitis; thymoquinone
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Al-Thobity, A.M.; Al-Khalifa, K.S.; Gad, M.M.; Al-Hariri, M.; Ali, A.A.; Alnassar, T. In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention. Int. J. Environ. Res. Public Health 2017, 14, 743.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top