Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women
AbstractBlood lead levels (BLLs) and delta-aminolevulinic acid dehydratase (ALAD) activity are considered biomarkers of lead exposure and lead toxicity, respectively. The present study was designed to investigate the association between BLLs and ALAD activity in pregnant women from Durango, Mexico. A total of 633 pregnant women aged 13–43 years participated in this study. Blood lead was measured by a graphite furnace atomic absorption spectrometer. ALAD activity was measured spectrophotometrically. Mean blood lead was 2.09 ± 2.34 µg/dL; and 26 women (4.1%) crossed the Centers for Disease Control (CDC) recommended level of 5 µg/dL. ALAD activity was significantly lower in women with levels of lead ≥5 µg/dL compared to those with BLLs < 5 µg/dL (p = 0.002). To reduce the influence of extreme values on the statistical analysis, BLLs were analyzed by quartiles. A significant negative correlation between blood lead and ALAD activity was observed in the fourth quartile of BLLs (r = −0.113; p < 0.01). Among women with blood lead concentrations ≥2.2 µg/dL ALAD activity was negatively correlated with BLLs (r = −0.413; p < 0.01). Multiple linear regression demonstrated that inhibition of ALAD in pregnant women may occur at levels of lead in blood above 2.2 µg/dL. View Full-Text
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La-Llave-León, O.; Méndez-Hernández, E.M.; Castellanos-Juárez, F.X.; Esquivel-Rodríguez, E.; Vázquez-Alaniz, F.; Sandoval-Carrillo, A.; García-Vargas, G.; Duarte-Sustaita, J.; Candelas-Rangel, J.L.; Salas-Pacheco, J.M. Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women. Int. J. Environ. Res. Public Health 2017, 14, 432.
La-Llave-León O, Méndez-Hernández EM, Castellanos-Juárez FX, Esquivel-Rodríguez E, Vázquez-Alaniz F, Sandoval-Carrillo A, García-Vargas G, Duarte-Sustaita J, Candelas-Rangel JL, Salas-Pacheco JM. Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women. International Journal of Environmental Research and Public Health. 2017; 14(4):432.Chicago/Turabian Style
La-Llave-León, Osmel; Méndez-Hernández, Edna M.; Castellanos-Juárez, Francisco X.; Esquivel-Rodríguez, Eloísa; Vázquez-Alaniz, Fernando; Sandoval-Carrillo, Ada; García-Vargas, Gonzalo; Duarte-Sustaita, Jaime; Candelas-Rangel, Jorge L.; Salas-Pacheco, José M. 2017. "Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women." Int. J. Environ. Res. Public Health 14, no. 4: 432.
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