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Int. J. Environ. Res. Public Health 2017, 14(2), 211; doi:10.3390/ijerph14020211

Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population

1
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2
Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
3
Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China
4
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 12 January 2017 / Revised: 4 February 2017 / Accepted: 8 February 2017 / Published: 21 February 2017
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [962 KB, uploaded 21 February 2017]   |  

Abstract

Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. BSG rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood BSG mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. BSG rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72–0.96, p = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68–0.95, p = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69–0.96, p = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased BSG mRNA in whole blood from 338 healthy normal donors (p = 1.31 × 10−6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population. View Full-Text
Keywords: Basigin; polymorphism; chronic heart failure; prognosis Basigin; polymorphism; chronic heart failure; prognosis
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MDPI and ACS Style

Li, M.-P.; Hu, X.-L.; Yang, Y.-L.; Zhang, Y.-J.; Zhou, J.-P.; Peng, L.-M.; Tang, J.; Chen, X.-P. Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population. Int. J. Environ. Res. Public Health 2017, 14, 211.

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