Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population
AbstractLeft ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. BSG rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood BSG mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. BSG rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72–0.96, p = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68–0.95, p = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69–0.96, p = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased BSG mRNA in whole blood from 338 healthy normal donors (p = 1.31 × 10−6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population. View Full-Text
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Li, M.-P.; Hu, X.-L.; Yang, Y.-L.; Zhang, Y.-J.; Zhou, J.-P.; Peng, L.-M.; Tang, J.; Chen, X.-P. Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population. Int. J. Environ. Res. Public Health 2017, 14, 211.
Li M-P, Hu X-L, Yang Y-L, Zhang Y-J, Zhou J-P, Peng L-M, Tang J, Chen X-P. Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population. International Journal of Environmental Research and Public Health. 2017; 14(2):211.Chicago/Turabian Style
Li, Mu-Peng; Hu, Xiao-Lei; Yang, Yong-Long; Zhang, Yan-Jiao; Zhou, Ji-Peng; Peng, Li-Ming; Tang, Jie; Chen, Xiao-Ping. 2017. "Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population." Int. J. Environ. Res. Public Health 14, no. 2: 211.