Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study
Abstract
:1. Background
2. Methods
2.1. Study Population
2.2. Biomarkers Selection and Measurements
2.3. Outcomes
2.4. Statistical Analysis
3. Results
3.1. Hyperuricemia Incidence and Baseline Characteristics
3.2. Construction of Prediction Models
3.3. Evaluation of Prediction Models
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
BMI | body mass index |
SBP | systolic blood pressure |
TG | triglycerides |
CHOL | total cholesterol |
HDL-C | high-density lipoprotein cholesterol |
LDL-C | low-density lipoprotein cholesterol |
SUA | serum uric acid |
SCr | serum creatinine |
ALT | alanine aminotransferase |
HUA | Hyperuricemia |
CI | Confidence interval |
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Variables | Males | p-Value | Females | p-Value | ||
---|---|---|---|---|---|---|
HUA | Non-HUA | HUA | Non-HUA | |||
(n = 5581) | (n = 29,395) | (n = 1554) | (n = 22,008) | |||
Age (years) | 41.69 ± 12.91 | 43.85 ± 13.42 | <0.0001 | 45.48 ± 14.59 | 41.21 ± 12.41 | <0.0001 |
SBP (mmHg) | 132.6 ± 17.37 | 130.4 ± 17.32 | <0.0001 | 127.7 ± 21.18 | 120.5 ± 18.11 | <0.0001 |
BMI (kg/m2) | 25.98 ± 3.12 | 24.91 ± 3.23 | <0.0001 | 24.35 ± 3.57 | 22.61 ± 3.21 | <0.0001 |
SUA (µmol/L) | 369.4 ± 40.94 | 320.5 ± 52.86 | <0.0001 | 294.7 ± 45.21 | 245.0 ± 47.89 | <0.0001 |
CHOL (mmol/L) | 4.97 ± 0.93 | 4.83 ± 0.90 | <0.0001 | 5.06 ± 1.02 | 4.75 ± 0.93 | <0.0001 |
TG (mmol/L) | 1.91 ± 1.56 | 1.54 ± 1.26 | <0.0001 | 1.41 ± 0.92 | 1.07 ± 0.77 | <0.0001 |
HDL-C (mmol/L) | 1.31 ± 0.31 | 1.35 ± 0.32 | <0.0001 | 1.47 ± 0.33 | 1.54 ± 0.35 | <0.0001 |
LDL-C (mmol/L) | 2.95 ± 0.73 | 2.86 ± 0.72 | <0.0001 | 2.95 ± 0.81 | 2.68 ± 0.75 | <0.0001 |
SCr (µmol/L) | 71.25 ± 13.63 | 70.04 ± 14.91 | <0.0001 | 54.35 ± 10.61 | 52.97 ± 11.18 | <0.0001 |
ALT (U/L) | 30.31 ± 23.31 | 26.62 ± 21.95 | <0.0001 | 20.47 ± 13.89 | 17.30 ± 14.86 | <0.0001 |
Variables | Sample Characteristics | HR (95% CI) | p-Value |
---|---|---|---|
Males | |||
Age (years) | 43.50 (13.36) | 0.990 (0.988–0.992) | <0.0001 |
SBP (mmHg) | 130.75 (17.34) | 1.009 (1.008–1.011) | <0.0001 |
BMI (kg/m2) | 25.08 (3.23) | 1.101 (1.093–1.109) | <0.0001 |
SUA (µmol/L) | 328.35 (54.18) | 1.022 (1.022–1.023) | <0.0001 |
CHOL (mmol/L) | 4.86 (0.91) | 1.156 (1.124–1.189) | <0.0001 |
TG (mmol/L) | 1.60 (1.32) | 1.105 (1.093–1.118) | <0.0001 |
HDL-C (mmol/L) | 1.35 (0.32) | 0.741 (0.681–0.806) | 0.0004 |
LDL-C (mmol/L) | 2.87 (0.72) | 1.217 (1.171–1.261) | <0.0001 |
SCr (µmol/L) | 70.23 (14.72) | 1.006 (1.005–1.006) | <0.0001 |
ALT (U/L) | 27.21 (22.21) | 1.004 (1.003–1.004) | <0.0001 |
Females | |||
Age (years) | 41.49 (12.61) | 1.025(1.021–1.029) | <0.0001 |
SBP (mmHg) | 120.93 (18.42) | 1.014 (1.011–1.017) | <0.0001 |
BMI (kg/m2) | 22.72 (3.26) | 1.095 (1.085–1.106) | <0.0001 |
SUA (µmol/L) | 248.28 (49.28) | 1.023 (1.022–1.024) | <0.0001 |
CHOL (mmol/L) | 4.77 (0.94) | 1.160 (1.098–1.224) | 0.0034 |
TG (mmol/L) | 1.08 (0.78) | 1.161 (1.130–1.193) | <0.0001 |
HDL-C (mmol/L) | 1.53 (0.35) | 0.653 (0.565–0.754) | 0.0019 |
LDL-C (mmol/L) | 2.70 (0.76) | 1.320 (1.237–1.410) | <0.0001 |
SCr (µmol/L) | 53.06 (11.15) | 1.005 (1.003–1.006) | 0.0209 |
ALT (U/L) | 17.51 (14.82) | 1.004 (1.003–1.006) | <0.0001 |
Variables | β Coefficient | SE | HR (95% CI) | p-Value |
---|---|---|---|---|
Males | ||||
Age (years) | −0.00891 | 0.0012 | 0.991 (0.989–0.993) | <0.0001 |
SBP (mmHg) | 0.00445 | 0.0010 | 1.004 (1.003–1.006) | <0.0001 |
BMI (kg/m2) | 0.03744 | 0.0054 | 1.042 (1.033–1.051) | <0.0001 |
SUA (µmol/L) | 0.02095 | 0.0004 | 1.022 (1.021–1.022) | <0.0001 |
Females | ||||
BMI (kg/m2) | 0.04934 | 0.0071 | 1.051 (1.036–1.065) | <0.0001 |
SBP (mmHg) | 0.00523 | 0.0016 | 1.005 (1.003–1.008) | <0.0001 |
SUA (µmol/L) | 0.02196 | 0.0006 | 1.022 (1.021–1.023) | <0.0001 |
TG (mmol/L) | 0.04633 | 0.0235 | 1.047 (1.000–1.097) | 0.0483 |
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Cao, J.; Wang, C.; Zhang, G.; Ji, X.; Liu, Y.; Sun, X.; Yuan, Z.; Jiang, Z.; Xue, F. Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study. Int. J. Environ. Res. Public Health 2017, 14, 67. https://doi.org/10.3390/ijerph14010067
Cao J, Wang C, Zhang G, Ji X, Liu Y, Sun X, Yuan Z, Jiang Z, Xue F. Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study. International Journal of Environmental Research and Public Health. 2017; 14(1):67. https://doi.org/10.3390/ijerph14010067
Chicago/Turabian StyleCao, Jin, Chunxia Wang, Guang Zhang, Xiang Ji, Yanxun Liu, Xiubin Sun, Zhongshang Yuan, Zheng Jiang, and Fuzhong Xue. 2017. "Incidence and Simple Prediction Model of Hyperuricemia for Urban Han Chinese Adults: A Prospective Cohort Study" International Journal of Environmental Research and Public Health 14, no. 1: 67. https://doi.org/10.3390/ijerph14010067