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Visualising and Thinking and Interpreting. Response to the Burstyn and De Roos Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
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Int. J. Environ. Res. Public Health 2017, 14(1), 5; doi:10.3390/ijerph14010005

Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559

Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 7 December 2016 / Accepted: 14 December 2016 / Published: 22 December 2016
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [521 KB, uploaded 22 December 2016]   |  

Abstract

We address a methodological issue of the evaluation of the difference in effects in epidemiological studies that may arise, for example, from stratum-specific analyses or differences in analytical decisions during data analysis. We propose a new simulation-based method to quantify the plausible extent of such heterogeneity, rather than testing a hypothesis about its existence. We examine the contribution of the method to the debate surrounding risk of multiple myeloma and glyphosate use and propose that its application contributes to a more balanced weighting of evidence. View Full-Text
Keywords: simulation; epidemiology; homogeneity; effect size simulation; epidemiology; homogeneity; effect size
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Burstyn, I.; De Roos, A.J. Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559. Int. J. Environ. Res. Public Health 2017, 14, 5.

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