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Int. J. Environ. Res. Public Health 2017, 14(1), 36; doi:10.3390/ijerph14010036

Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population

1
Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China
2
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
3
School of Public Health, Southeast University, Nanjing 210009, China
4
Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jose A. Centeno
Received: 17 October 2016 / Revised: 11 December 2016 / Accepted: 14 December 2016 / Published: 31 December 2016
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [279 KB, uploaded 5 January 2017]

Abstract

Lead (Pb) is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP in XPO5 extron (rs2257082) was significantly associated with lead-poisoning (p = 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07–2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions. View Full-Text
Keywords: lead-sensitive and resistant; blood leads level; XPO5 polymorphism; miRNA regulation lead-sensitive and resistant; blood leads level; XPO5 polymorphism; miRNA regulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, H.; Xu, M.; Zhao, Q.; Sun, K.; Gong, W.; Zhang, Q.; Zhu, B.; An, Y. Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population. Int. J. Environ. Res. Public Health 2017, 14, 36.

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